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Effects of the Circadian Rhythm Gene Period 1 (Per1) on Psychosocial Stress-Induced Alcohol Drinking

Dong, Li ; Bilbao, Ainhoa ; Laucht, Manfred ; Henriksson, Richard ; Yakovleva, Tatjana ; Ridinger, Monika ; Desrivieres, Sylvane ; Clarke, Toni-Kim ; Lourdusamy, Anbarasu ; Smolka, Michael N. ; Cichon, Sven ; Blomeyer, Dorothea ; Treutlein, Jens ; Perreau-Lenz, Stephanie ; Witt, Stephanie ; Leonardi-Essmann, Fernando ; Wodarz, Norbert ; Zill, Peter ; Soyka, Michael ; Albrecht, Urs ; Rietschel, Marcella ; Lathrop, Mark ; Bakalkin, Georgy ; Spanagel, Rainer ; Schumann, Gunter



Zusammenfassung

Objective: Circadian and stress-response systems mediate environmental changes that affect alcohol drinking. Psychosocial stress is an environmental risk factor for alcohol abuse. Circadian rhythm gene period 1(Per1) is targeted by stress hormones and is transcriptionally activated in corticotropin releasing factor-expressing cells. The authors hypothesized that Per1 is involved in integrating ...

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