Catechol, a Bioactive Degradation Product of Salicortin, Reduces TNF-αInduced ICAM-1 Expression in Human Endothelial Cells

Knuth, Susanne ; Schübel, Helmut ; Hellemann, Martin ; Jürgenliemk, Guido

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Zusammenfassung

The phenolic glucoside salicortin was isolated from a Willow bark extract, and its ability to reduce the TNF-alpha induced ICAM-1 expression (10 ng/mL, 30 min pretreatment with salicortin) was tested in vitro on human microvascular endothelial cells (HMEC-1). After 24 h, 25 mu M salicortin decreased the TNF-a induced ICAM-1 expression to 65.9% compared to cells which were treated only with TNF-a. ...