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Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study

Preuss, Ulrich W. ; Ridinger, Monika ; Rujescu, Dan ; Samochowiec, Jerzy ; Fehr, Christoph ; Wurst, Friedrich M. ; Koller, Gabriele ; Bondy, Brigitta ; Wodarz, Norbert ; Debniak, Tadeusz ; Grzywacz, Anna ; Soyka, Michael ; Zill, Peter



Zusammenfassung

Genetic variants of the alcohol-metabolizing enzyme ADH4, located on chromosome 4q22-4q23, have been related to alcohol dependence (AD) risk in previous research. The aim of this association study in a large multicenter sample of alcohol-dependent individuals and controls is to confirm ADH4 single nucleotide polymorphism (SNP) and haplotype association with AD and relevant related phenotypes. One ...

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