Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors
Chen, Xinyu, Tikhonova, Irina G. and Decker, Michael (2011) Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors. Bioorganic & Medicinal Chemistry 19 (3), pp. 1222-1235.Date of publication of this fulltext: 19 Dec 2024 11:15
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| Item type | Article | ||||
| Journal or Publication Title | Bioorganic & Medicinal Chemistry | ||||
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | ||||
|---|---|---|---|---|---|
| Place of Publication: | OXFORD | ||||
| Volume: | 19 | ||||
| Number of Issue or Book Chapter: | 3 | ||||
| Page Range: | pp. 1222-1235 | ||||
| Date | 2011 | ||||
| Institutions | Chemistry and Pharmacy > Institute of Pharmacy | ||||
| Identification Number |
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| Keywords | ACETYLCHOLINESTERASE INHIBITORS; HETERO-BIVALENT; RATIONAL DESIGN; ACTIVE-SITE; BINDING; LIGANDS; FLUCTUATIONS; RECEPTORS; SALTS; Alzheimer's disease; Cholinesterase; Molecular docking; Bivalent inhibitors; Quinazolinimines | ||||
| Dewey Decimal Classification | 600 Technology > 615 Pharmacy | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | Yes | ||||
| Item ID | 65246 |
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