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Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer

Kim, Dong-Hyun ; Smith-Warner, Stephanie A. ; Spiegelman, Donna ; Yaun, Shiaw-Shyuan ; Colditz, Graham A. ; Freudenheim, Jo L. ; Giovannucci, Edward ; Goldbohm, R. Alexandra ; Graham, Saxon ; Harnack, Lisa ; Jacobs, Eric J. ; Leitzmann, Michael ; Mannisto, Satu ; Miller, Anthony B. ; Potter, John D. ; Rohan, Thomas E. ; Schatzkin, Arthur ; Speizer, Frank E. ; Stevens, Victoria L. ; Stolzenberg-Solomon, Rachael ; Terry, Paul ; Toniolo, Paolo ; Weijenberg, Matty P. ; Willett, Walter C. ; Wolk, Alicja ; Zeleniuch-Jacquotte, Anne ; Hunter, David J.



Zusammenfassung

Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. Study- and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model. Among 725,134 participants, 5,720 incident colon cancers were ...

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