Dokumentenart: | Artikel | ||||
---|---|---|---|---|---|
Titel eines Journals oder einer Zeitschrift: | Nature Genetics | ||||
Verlag: | NATURE PUBLISHING GROUP | ||||
Ort der Veröffentlichung: | NEW YORK | ||||
Band: | 42 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 11 | ||||
Seitenbereich: | S. 937-948 | ||||
Datum: | 2010 | ||||
Institutionen: | Medizin > Lehrstuhl für Innere Medizin II Medizin > Institut für Epidemiologie und Präventivmedizin | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | GENOME-WIDE ASSOCIATION; GASTRIC-INHIBITORY POLYPEPTIDE; COMMON VARIANTS; EARLY-ONSET; FTO GENE; FAT MASS; OBESITY; GLUCOSE; METAANALYSIS; WEIGHT; | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 65644 |
Zusammenfassung
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci ...
Zusammenfassung
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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