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Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: Results of genome-wide association analyses including 4659 European individuals

Heid, Iris M. ; Henneman, Peter ; Hicks, Andrew ; Coassin, Stefan ; Winkler, Thomas ; Aulchenko, Yurii S. ; Fuchsberger, Christian ; Song, Kijoung ; Hivert, Marie-France ; Waterworth, Dawn M. ; Timpson, Nicholas J. ; Richards, J. Brent ; Perry, John R.B. ; Tanaka, Toshiko ; Amin, Najaf ; Kollerits, Barbara ; Pichler, Irene ; Oostra, Ben A. ; Thorand, Barbara ; Frants, Rune R. ; Illig, Thomas ; Dupuis, Josée ; Glaser, Beate ; Spector, Tim ; Guralnik, Jack ; Egan, Josephine M. ; Florez, Jose C. ; Evans, David M. ; Soranzo, Nicole ; Bandinelli, Stefania ; Carlson, Olga D. ; Frayling, Timothy M. ; Burling, Keith ; Smith, George Davey ; Mooser, Vincent ; Ferrucci, Luigi ; Meigs, James B. ; Vollenweider, Peter ; Dijk, Ko Willems van ; Pramstaller, Peter ; Kronenberg, Florian ; van Duijn, Cornelia M.



Zusammenfassung

Objective: Plasma adiponectin is strongly associated with various components of metabolic syndrome, type 2 diabetes and cardiovascular outcomes. Concentrations are highly heritable and differ between men and women. We therefore aimed to investigate the genetics of plasma adiponectin in men and women. Methods: Wecombined genome-wide association scans of three population-based studies including ...

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