Bis(1H‐indol‐2‐yl)methanones are effective inhibitors of FLT3‐ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro
Heidel, Florian, Lipka, Daniel B., Mirea, Fian K., Mahboobi, Siavosh, Grundler, Rebekka, Kancha, Rama K., Duyster, Justus, Naumann, Michael
, Huber, Christoph, Böhmer, Frank D. and Fischer, Thomas
(2009)
Bis(1H‐indol‐2‐yl)methanones are effective inhibitors of FLT3‐ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro.
British Journal of Haematology 144 (6), pp. 865-874.
Date of publication of this fulltext: 19 Dec 2024 12:10
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| Item type | Article | ||||
| Journal or Publication Title | British Journal of Haematology | ||||
| Publisher: | WILEY-BLACKWELL | ||||
|---|---|---|---|---|---|
| Place of Publication: | HOBOKEN | ||||
| Volume: | 144 | ||||
| Number of Issue or Book Chapter: | 6 | ||||
| Page Range: | pp. 865-874 | ||||
| Date | 2009 | ||||
| Institutions | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) | ||||
| Identification Number |
| ||||
| Keywords | ACUTE MYELOID-LEUKEMIA; INTERNAL TANDEM DUPLICATION; ACUTE MYELOGENOUS LEUKEMIA; ACTIVATING MUTATION; MYELODYSPLASTIC SYNDROME; JUXTAMEMBRANE DOMAIN; OLDER PATIENTS; CELL-LINES; AML; CHEMOTHERAPY; acute myeloid leukaemia; tyrosine kinase inhibitor; resistance; small molecule; fms-like tyrosine kinase 3 | ||||
| Dewey Decimal Classification | 600 Technology > 615 Pharmacy | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | Yes | ||||
| Item ID | 67344 |
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