Zusammenfassung
Objectives. -Increasing evidence suggests that dysfunctions of the cortico-cerebello-thalamocortical circuit are involved in the pathophysiology of neuropsychiatric disorders. This study explores the effects of cerebellar repetitive transcranial magnetic stimulation (rTMS) on cerebetto-thalamocortical pathways. Methods. -Ten healthy volunteers received MRI-guided rTMS in four separate sessions ...
Zusammenfassung
Objectives. -Increasing evidence suggests that dysfunctions of the cortico-cerebello-thalamocortical circuit are involved in the pathophysiology of neuropsychiatric disorders. This study explores the effects of cerebellar repetitive transcranial magnetic stimulation (rTMS) on cerebetto-thalamocortical pathways. Methods. -Ten healthy volunteers received MRI-guided rTMS in four separate sessions (120% motor threshold, 1000 stimuli) over either the medial or the right lateral cerebellum using frequencies of 1 and 10 Hz. Motor cortex excitability was assessed before and after the intervention by paired-pulse transcranial magnetic stimulation. Results. -Depending on stimulation frequency, cerebellar rTMS differentially modified intracortical inhibition. Low frequency rTMS increased short intracortical inhibition (SICI), whereas high frequency rTMS had no significant effect on SICI. Conclusions. -These results suggest that rTMS over the cerebellum can modulate cerebello-thalamocortical, pathways in a frequency-specific manner. (c) 2008 Elsevier Masson SAS. All rights reserved.
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