Herwig, Uwe ; Fallgatter, Andreas J. ; Höppner, Jacqueline ; Eschweiler, Gerhard W. ; Kron, Martina ; Hajak, Göran ; Padberg, Frank ; Naderi-Heiden, Angela ; Abler, Birgit ; Eichhammer, Peter ; Grossheinrich, Nicola ; Haya, Birgit ; Kammer, Thomas 
; Langguth, Berthold ; Laske, Christoph ; Plewnia, Christian ; Richter, Melany M. ; Schulz, Merten ; Unterecker, Stefan ; Zinke, Antonia ; Spitzer, Manfred ; Schönfeldt-Lecuona, Carlos
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | British Journal of Psychiatry |
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| Verlag: | ROYAL COLLEGE OF PSYCHIATRISTS |
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| Ort der Veröffentlichung: | LONDON |
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| Band: | 191 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 5 |
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| Seitenbereich: | S. 441-448 |
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| Datum: | 2007 |
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| Institutionen: | Medizin > Lehrstuhl für Psychiatrie und Psychotherapie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1192/bjp.bp.106.034371 | DOI |
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| Stichwörter / Keywords: | MAJOR DEPRESSIVE DISORDER; DOUBLE-BLIND; RESISTANT DEPRESSION; PREFRONTAL CORTEX; TMS TREATMENT; EFFICACY; RTMS; METAANALYSIS; VENLAFAXINE; SERTRALINE; |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 68726 |
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Web of Science
Zusammenfassung
Background Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a new treatment option for depression. Previous studies were performed with low sample sizes in single centres and reported heterogeneous results. Aims To investigate the efficacy of as augmentative treatment in depression. Method In a randomised, double-blind, sham-controlled multicentre trial 127 patients with ...
Zusammenfassung
Background Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a new treatment option for depression. Previous studies were performed with low sample sizes in single centres and reported heterogeneous results. Aims To investigate the efficacy of as augmentative treatment in depression. Method In a randomised, double-blind, sham-controlled multicentre trial 127 patients with moderate to severe depressive episodes were randomly assigned to real or sham stimulation for 3 weeks in addition to simultaneously initiated antidepressant medication. Results We found no difference in the responder rates of the real and the sham treatment groups (31% in each) or in the decrease of the scores on the depression rating scales. Conclusions The data do not support previous reports from smaller samples indicating an augmenting or accelerating antidepressant effect of rTMS. Further exploration of the possible efficacy of other stimulation protocols or within selected sub-populations of patients is necessary.
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