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Bivalent argininamide-type neuropeptide Y Y1 antagonists do not support the hypothesis of receptor dimerisation

Keller, Max, Teng, Shangjun, Bernhardt, Günther and Buschauer, Armin (2009) Bivalent argininamide-type neuropeptide Y Y1 antagonists do not support the hypothesis of receptor dimerisation. ChemMedChem 4 (10), pp. 1733-1745.

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Other URL: http://www3.interscience.wiley.com/journal/122543323/abstract, http://www.ncbi.nlm.nih.gov/pubmed/19672917?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


Bivalent ligands are potential tools to investigate the dimerisation of G-protein-coupled receptors. Based on the (R)-argininamide BIBP 3226, a potent and selective neuropeptide Y Y1 receptor (Y1R) antagonist, we prepared a series of bivalent Y1R ligands using a wide range of linker lengths (8 to 36 atoms). Exploiting the high eudismic ratio (>1000) of the parent compound we synthesized sets of ...


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Item type:Article
Date:11 August 2009
Additional Information (public):Supporting Information available
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
19672917PubMed ID
Related URLs:
http://www3.interscience.wiley.com/cgi-bin/fulltext/122543323/sm001.pdf?PLACEBO=IE.pdfSupplementary Material
Keywords:Y1 antagonist; bridging ligands; dimerisation; neuropeptide Y; receptor
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:6926
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