Zusammenfassung
The design, synthesis and biological evaluation of lexitropsins bearing mixed heterocyclic and benzoheterocyclic moieties and tethered to an alpha-bromo acrylic moiety acting as alkylating moiety are reported, and structure-activity relationships determined. With respect to anti proliferative activity against L1210 and K562 cells, compounds 7 and 10 showed the greatest potency, while compounds 4 ...
