Wodarz, Norbert ; Lange, Kirsten ; Laufkötter, Rainer ; Johann, Monika
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Psychiatrische Praxis |
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| Verlag: | GEORG THIEME VERLAG KG |
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| Ort der Veröffentlichung: | STUTTGART |
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| Band: | 31 |
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| Seitenbereich: | S. 111-113 |
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| Datum: | 2004 |
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| Institutionen: | Medizin > Lehrstuhl für Psychiatrie und Psychotherapie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1055/s-2004-828449 | DOI |
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| Stichwörter / Keywords: | DEFICIT HYPERACTIVITY DISORDER; PROMOTER REGION POLYMORPHISM; SEROTONIN TRANSPORTER GENE; PROLACTIN RESPONSE; FENFLURAMINE; PERSONALITY; ASSOCIATION; 5-HTTLPR; RECEPTOR; ABUSE; |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 71230 |
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Web of Science
Zusammenfassung
Introduction: Nearly 50% of subjects with continuing symptoms of attention-deficit hyperactivity disorder (ADHD) in adulthood show a comorbid substance use disorder. Both, ADHD and alcohol dependence have a high genetic load and might even share overlapping sources of genetic liability. Method: We investigated phenotype and 5-HTT/5-HT2c allelic characteristics in 314 alcoholics of German descent. ...
Zusammenfassung
Introduction: Nearly 50% of subjects with continuing symptoms of attention-deficit hyperactivity disorder (ADHD) in adulthood show a comorbid substance use disorder. Both, ADHD and alcohol dependence have a high genetic load and might even share overlapping sources of genetic liability. Method: We investigated phenotype and 5-HTT/5-HT2c allelic characteristics in 314 alcoholics of German descent. Result: 21 % of the alcoholics fulfilled DSM-IV-criteria of ADHD with ongoing symptoms in adulthood. There was no significant difference in 5-HTT- or 5-HT2c-allele distribution between alcoholics and matched controls or between alcoholics with or without ADHD. Conclusion: In our sample the functional relevant 5-HTT-promoter and the 5-HT2c-receptor Cys23Ser polymorphism do not contribute to the supposed common genetic predisposition of ADHD and alcohol dependence.
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