Eichhammer, Peter ; Langguth, Berthold ; Wiegand, Rainer ; Kharraz, Alexander ; Frick, Ulrich ; Hajak, Göran
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Psychopharmacology |
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| Verlag: | SPRINGER-VERLAG |
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| Ort der Veröffentlichung: | NEW YORK |
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| Band: | 166 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 3 |
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| Seitenbereich: | S. 294-297 |
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| Datum: | 2003 |
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| Institutionen: | Medizin > Lehrstuhl für Psychiatrie und Psychotherapie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1007/s00213-002-1370-1 | DOI |
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| Stichwörter / Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; MOTOR CORTEX EXCITABILITY; PREFRONTAL CORTEX; BRAIN; CITALOPRAM; GENE; POLYMORPHISM; VARIABILITY; EXPRESSION; DEPRESSION; paired pulse transcranial magnetic stimulation; serotonin gene transporter polymorphism; serotonin transporter reuptake inhibitor; motor cortex excitability |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 72402 |
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Web of Science
Zusammenfassung
Rationale: Antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs) has been shown to depend on functional polymorphisms within the promoter region of the serotonin transporter gene (5-HTTLPR). This gene gives rise to a biallelic polymorphism designated long (1) and short (s). Homozygosity for the long variant (11-genotype) is associated with a two times more efficient 5-HT ...
Zusammenfassung
Rationale: Antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs) has been shown to depend on functional polymorphisms within the promoter region of the serotonin transporter gene (5-HTTLPR). This gene gives rise to a biallelic polymorphism designated long (1) and short (s). Homozygosity for the long variant (11-genotype) is associated with a two times more efficient 5-HT uptake compared to the s/l- or s/sgenotype. Paired pulse transcranial magnetic stimulation is a feasible tool in detecting changes of motor cortex excitability induced by SSRIs. Objective: Our study aimed to measure neuromodulatory effects of SSRIs on cortical excitability in healthy volunteers characterized by distinct genotypes of the 5-HTTLPR. Methods: Cortical excitability was determined in eight genetically defined subjects pre- and post-ingestion of 60 mg citalopram. Results: Subjects with the 11-genotype of the 5-HTTLPR showed a significant enhancement of a particular component of motor cortex excitability (intracortical inhibition) as compared to volunteers without the 11-genotype. Conclusion: Distinct neuromodulatory effects after intake of citalopram based on allelic variations of the 5-HTTLPR may explain variable response of patients treated with SSRIs.
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