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Cyclosporine A Suppresses Cyclooxygenase-2 Expression in the Rat Kidney

Ho[Combining Diaeresis]cherl, Klaus ; Dreher, Franziska ; Vitzthum, Helga ; Ko[Combining Diaeresis]hler, Jens ; Kurtz, Armin



Zusammenfassung

On the basis of recent evidence that the cyclooxygenase-2 (COX-2) gene promoter contains functional binding sites for the nuclear factor of activated T cells (NFAT) and that COX-2 is expressed in a regulated fashion in the kidney, this study aimed to assess the effect of immunosuppressants on COX-2 expression in the kidney. Therefore, Wistar-Kyoto rats were treated with cyclosporine A (CsA; 15 ...

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