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Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

Sklar, Pamela ; Schwab, Sibylle G. ; Williams, Nigel M. ; Daly, Mark ; Schaffner, Stephen ; Maier, Wolfgang ; Albus, Margot ; Trixler, Matyas ; Eichhammer, Peter ; Lerer, Bernard ; Hallmayer, Joachim ; Norton, Nadine ; Williams, Hywel ; Zammit, Stan ; Cardno, Alastair G. ; Jones, Sue ; McCarthy, Geraldine ; Milanova, Vihra ; Kirov, George ; O'Donovan, Michael C. ; Lander, Eric S. ; Owen, Michael J. ; Wildenauer, Dieter B.



Zusammenfassung

A genetic association between NOTCH4 and schizophrenia has previously been proposed(1). Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observaton, These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.


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