Optical Control of TRPM8 Channels with Photoswitchable Menthol

URN to cite this document:: urn:nbn:de:bvb:355-epub-745551
DOI to cite this document:: 10.5283/epub.74555

Becker, Jasmin ; Ellerkmann, Clara S. ; Schmelzer, Hannah ; Hermann, Christian ; Lützel, Kyra ; Gudermann, Thomas ; Konrad, David B. ; Trauner, Dirk ; Storch, Ursula

; Mederos y Schnitzler, Michael

License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 07 Jan 2025 10:32

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Abstract

Transient receptor potential melastatin 8 (TRPM8) channels are well known as sensors for cold temperatures and cooling agents such as menthol and icilin and these channels are tightly regulated by the membrane lipid phosphoinositol-4,5-bisphosphate (PIP2). Since TRPM8 channels emerged as promising drug targets for treating pain, itching, obesity, cancer, dry eye disease, and inflammation, we ...