A naturally occurring standalone TrpB enzyme provides insights into allosteric communication within tryptophan synthase

URN to cite this document:: urn:nbn:de:bvb:355-epub-764073
DOI to cite this document:: 10.5283/epub.76407

Kinateder, Thomas

; Drexler, Lukas ; Duran, Cristina ; Osuna, Sílvia ; Sterner, Reinhard

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Mar 2025 10:50

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Abstract

Allosteric regulation of catalytic activity is a widespread property of multi-enzyme complexes. The tryptophan synthase is a prototypical allosteric enzyme where the constituting α (TrpA) and β (TrpB) subunits mutually activate each other in a manner that is incompletely understood. Experimental and computational studies have shown that LBCA-TrpB from the last bacterial common ancestor contains ...