We prove that there exists an algorithm for determining whether two piecewise-linear spatial graphs are isomorphic. In its most general form, our theorem applies to spatial graphs furnished with vertex colourings, edge colourings and/or edge orientations.

We first show that spatial graphs admit canonical decompositions into blocks, that is, spatial graphs that are non-split and have no cut vertices, in a suitable topological sense. Then, we apply a result of Haken and Matveev in order to algorithmically distinguish these blocks.