Schreiber, Stefan ; Waetzig, Georg H. ; López-Agudelo, Víctor A. ; Geisler, Corinna ; Schlicht, Kristina ; Franzenburg, Sina ; di Giuseppe, Romina ; Pape, Daniel ; Bahmer, Thomas ; Krawczak, Michael ; Kokott, Elisabeth ; Penninger, Josef M. ; Harzer, Oliver ; Kramer, Jan ; von Schrenck, Tammo ; Sommer, Felix ; Zacharias, Helena U. ; Bokemeyer, Bernd ; di Giuseppe, Romina ; Gronwald, Wolfram ; Harris, Danielle M. M. ; Hartmann, Katharina ; Hollstein, Tim ; Oefner, Peter J. 
; Plachta-Danielzik, Sandra ; Tran, Florian ; von Schrenck, Tammo ; Millet Pascual-Leone, Belén ; Forslund, Sofia K. ; Heyckendorf, Jan ; Aden, Konrad ; Hollweck, Regina ; Laudes, Matthias ; Rosenstiel, Philip
; Plachta-Danielzik, Sandra ; Tran, Florian ; von Schrenck, Tammo ; Millet Pascual-Leone, Belén ; Forslund, Sofia K. ; Heyckendorf, Jan ; Aden, Konrad ; Hollweck, Regina ; Laudes, Matthias ; Rosenstiel, Philip Zusammenfassung
Cellular NAD+ depletion, altered tryptophan metabolism and gut microbiome dysbiosis are associated with disease progression and unfavourable clinical outcomes in COVID-19. Here, we show that supplementing tryptophan metabolism with nicotinamide alleviates COVID-19 symptoms. We evaluate a 4-week intervention with a novel nicotinamide formulation (1,000 mg) in a prospective, double-blind, ...
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