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Damm, Carsten ; Goepferich, Achim

Dual cross-linked hydrogels as promising materials for drug delivery

Damm, Carsten und Goepferich, Achim (2025) Dual cross-linked hydrogels as promising materials for drug delivery. International Journal of Pharmaceutics 683, S. 125929.

Veröffentlichungsdatum dieses Volltextes: 05 Aug 2025 06:03
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.77498


Zusammenfassung

Hydrogels have long found their place as versatile materials for drug delivery due to their biocompatibility, tunable properties and tissue-like mechanical behavior. Despite these advantages they suffer from a multitude of drawbacks, ranging from lacking injectability and low mechanical strength to short drug release times. These factors limit their potential clinical applications. Dual ...

Hydrogels have long found their place as versatile materials for drug delivery due to their biocompatibility, tunable properties and tissue-like mechanical behavior. Despite these advantages they suffer from a multitude of drawbacks, ranging from lacking injectability and low mechanical strength to short drug release times. These factors limit their potential clinical applications. Dual cross-link hydrogels are a versatile tool to address these shortcomings. By combining covalent with dynamic-covalent and physical cross-linking they create smarter, stronger and more versatile hydrogels, broadening their applicability. This review aims to bridge the gap between traditional hydrogels and emerging dual cross-linked hydrogels by providing an overview of the chemistries involved. We discuss the most popular cross-linking strategies and how these can be used to address specific challenges in hydrogel design. Furthermore we highlight how recent research has utilized these promising materials to enable the application of hydrogels in ever more demanding environments.



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Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftInternational Journal of Pharmaceutics
Verlag:Elsevier, ScienceDirect
Band:683
Seitenbereich:S. 125929
Datum23 Juli 2025
InstitutionenChemie und Pharmazie > Institut für Pharmazie
Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Technologie (Prof. Göpferich)
Projekte
Gefördert von: Bundesministerium für Bildung und Forschung (BMBF) (16GW0363K)
Identifikationsnummer
WertTyp
10.1016/j.ijpharm.2025.125929DOI
Stichwörter / KeywordsDual cross-link hydrogels, Parenteral drug delivery, Hybrid cross-linking, Sustained release, Polymers, Tissue engineering
Dewey-Dezimal-Klassifikation600 Technik, Medizin, angewandte Wissenschaften > 615 Pharmazie
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenJa
URN der UB Regensburgurn:nbn:de:bvb:355-epub-774983
Dokumenten-ID77498

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