Harp: Data Harmonization for Computational Tissue Deconvolution across Diverse Transcriptomics Platforms

URN to cite this document:: urn:nbn:de:bvb:355-epub-777848
DOI to cite this document:: 10.5283/epub.77784

Nozari, Zahra

; Hüttl, Paul

; Simeth, Jakob

; Schön, Marian ; Hutchinson, James A.

; Spang, Rainer

; Nikolski, Macha

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Sep 2025 08:04

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Abstract

Motivation The cellular composition of a solid tissue can be assessed either through the physical dissociation of the tissue followed by single-cell analysis techniques or by computational deconvolution of bulk gene expression profiles. However, both approaches are prone to significant biases. Tissue dissociation often results in disproportionate cell loss, while deconvolution is hindered by ...