Zusammenfassung
Healthcare systems around the world are undergoing an organizational, methodological and
technological transformation towards personalized, preventive, predictive, participative precision
(5P) medicine ecosystems. These ecosystems consider individual health status, conditions,
genetic and genomic dispositions in personal social, occupational, environmental,
and behavioral contexts. For ...
Zusammenfassung
Healthcare systems around the world are undergoing an organizational, methodological and
technological transformation towards personalized, preventive, predictive, participative precision
(5P) medicine ecosystems. These ecosystems consider individual health status, conditions,
genetic and genomic dispositions in personal social, occupational, environmental,
and behavioral contexts. For designing and managing the resulting highly interdisciplinary,
complex, distributed and dynamic ecosystem, we must formally and consistently represent
the system and its components at necessary granularity levels from the perspective of all actors
including the subject of care. As those actors from different domains have different education,
skills, and experiences, using different methodologies, languages and terminologies,
communication and cooperation, i.e. interoperability, must advance from the data level (data
sharing) to the knowledge level (knowledge sharing). To understand the business system, it
must formally represent each considered use case structurally and functionally. Therefore,
the design, implementation and management of intelligent and ethical transformed ecosystems
must be realized, using a system-theoretical, architecture-centered, ontology-based
and policy-driven approach, developed by the author over the last 30 years. The related
model and framework have been meanwhile standardized as the ISO 23903 Interoperability
and Integration Reference Architecture, defined as mandatory for any specification or project
at ISO, CEN, IEEE, OMG, etc., addressing more than one domain. Thereby, it manages also security,
privacy and trust in detail. The Keynote introduces necessary standards and methodologies
for designing and managing 5P medicine ecosystems as well as practical examples.