Hagelüken, A. and Grünbaum, L. and Nürnberg, B. and Harhammer, R. and Schunack, W. and Seifert, Roland
Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins.
Biochemical pharmacology 47 (10), pp. 1789-1795.
We studied the effects of various beta-adrenoceptor (beta AR) antagonists and local anesthetics (LAs), i.e. substances possessing one basic and one lipophilic domain each, on activation of regulatory heterotrimeric guanine nucleotide-binding proteins (G-proteins). In membranes of differentiated HL-60 cells, propranolol activated high-affinity GTP hydrolysis with a half-maximal effect at 0.19 mM ...
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