Startseite UB

Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins

Hagelüken, A. and Grünbaum, L. and Nürnberg, B. and Harhammer, R. and Schunack, W. and Seifert, Roland (1994) Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins. Biochemical pharmacology 47 (10), pp. 1789-1795.

[img]
Preview
PDF
Download (923kB)

at PubMed


Abstract

We studied the effects of various beta-adrenoceptor (beta AR) antagonists and local anesthetics (LAs), i.e. substances possessing one basic and one lipophilic domain each, on activation of regulatory heterotrimeric guanine nucleotide-binding proteins (G-proteins). In membranes of differentiated HL-60 cells, propranolol activated high-affinity GTP hydrolysis with a half-maximal effect at 0.19 mM ...

plus


Export bibliographical data



Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
7911302PubMed ID
Classification:
NotationType
Adrenergic beta-Antagonists/pharmacologyMESH
Anesthetics, Local/pharmacologyMESH
Cell LineMESH
Cell Membrane/drug effectsMESH
GTP-Binding Proteins/metabolismMESH
HumansMESH
Lipid MetabolismMESH
Pertussis ToxinMESH
Propranolol/pharmacologyMESH
Tetracaine/pharmacologyMESH
Virulence Factors, Bordetella/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jan 2012 08:21
Last Modified:13 Mar 2014 18:30
Item ID:23299
Owner Only: item control page

Downloads

Downloads per month over past year

  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact