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N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions

Wenzel-Seifert, K. and Schächtele, C. and Seifert, Roland (1994) N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions. Biochemical and biophysical research communications 200 (3), pp. 1536-1543.

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Abstract

The role of protein kinase C (PKC) isoenzymes in the regulation of cell functions is largely unknown. We studied the effects of 2-(1H-indol-3-yl)-3- [1-(3-dimethylaminopropyl)-1H-indol-3-yl]-maleinimide (Gö 6850), a selective inhibitor of c- and n-PKC isoenzymes, and 12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2 ,3- a]pyrrolo[3, 4-c]-carbazole (Gö 6976), an inhibitor of c-PKC ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
8185608PubMed ID
Classification:
NotationType
Carbazoles/pharmacologyMESH
Enzyme ActivationMESH
HumansMESH
Indoles/pharmacologyMESH
Isoenzymes/metabolismMESH
Maleimides/pharmacologyMESH
Muramidase/metabolismMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Neutrophils/enzymologyMESH
Protein Kinase C/metabolismMESH
Respiratory Burst/drug effectsMESH
Superoxides/metabolismMESH
Tetradecanoylphorbol Acetate/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jan 2012 08:21
Last Modified:13 Mar 2014 18:30
Item ID:23300
Owner Only: item control page
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