Startseite UB

Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase

Klinker, J. F. and Hagelüken, A. and Grünbaum, L. and Heilmann, I. and Nürnberg, B. and Harhammer, R. and Offermanns, S. and Schwaner, I. and Ervens, J and Wenzel-Seifert, K and Müller, T. and Seifert, Roland (1994) Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase. The Biochemical journal 304 ( Pt 2, pp. 377-383.

[img]
Preview
PDF
Download (1MB)

at PubMed


Abstract

The wasp venom, mastoparan (MP), activates reconstituted pertussis toxin (PTX)-sensitive G-proteins in a receptor-independent manner. We studied the effects of MP and its analogue, mastoparan 7 (MP 7), on G-protein activation in HL-60 cells and a reconstituted system and on nucleoside diphosphate kinase (NDPK)-catalysed GTP formation. MP activated high-affinity GTP hydrolysis in HL-60 membranes ...

plus


Export bibliographical data



Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
7998971PubMed ID
Classification:
NotationType
Adenosine Diphosphate Ribose/metabolismMESH
Adenosine Triphosphatases/antagonists & inhibitorsMESH
Amino Acid SequenceMESH
AnimalsMESH
Calcium/metabolismMESH
CattleMESH
Cell Membrane/enzymologyMESH
GTP-Binding Proteins/metabolismMESH
Guanosine 5'-O-(3-Thiotriphosphate)/metabolismMESH
Guanosine Triphosphate/metabolismMESH
HumansMESH
HydrolysisMESH
Mitochondria, Liver/enzymologyMESH
Molecular Sequence DataMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Nucleoside-Diphosphate Kinase/metabolismMESH
PeptidesMESH
Pertussis ToxinMESH
Superoxides/metabolismMESH
Tumor Cells, CulturedMESH
Virulence Factors, Bordetella/pharmacologyMESH
Wasp Venoms/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jan 2012 08:28
Last Modified:13 Mar 2014 18:30
Item ID:23306
Owner Only: item control page

Downloads

Downloads per month over past year

  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact