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Interaktionen von Histamin H1-Rezeptoragonisten und
–antagonisten mit dem humanen Histamin H4-Rezeptor

URN to cite this document: urn:nbn:de:bvb:355-epub-235555

Deml, Karl-Friedrich (2012) Interaktionen von Histamin H1-Rezeptoragonisten und
–antagonisten mit dem humanen Histamin H4-Rezeptor.
PhD, Universität Regensburg.

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Abstract (German)

Der humane Histamin H(4)-Rezeptor (hH(4)R) zeichnet sich durch hohe konstitutive Aktivität aus und ist wie der humane H(1)-Rezeptor (hH(1)R) in die Pathogenese von allergischen Reaktionen vom Typ I involviert. Die Ziele der Untersuchungen waren die Evaluierung des Wertes von dualen H(1)/H(4)R Antagonisten als antiallergische Medikamente und die Klärung der Frage, ob H(1)R Liganden an den hH(4)R ...


Translation of the abstract (English)

The human histamine H(4)-receptor (hH(4)R) possesses high constitutive activity and, like the human H(1)-receptor (hH(1)R), is involved in the pathogenesis of type-I allergic reactions. The study aims were to explore the value of dual H(1)/H(4)R antagonists as antiallergy drugs and to address the question of whether H(1)R ligands bind to hH(4)R. At the hH(4)R expressed in Sf9 insect cells, 18 ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:20 March 2012
Referee:Prof. Dr. Jens Schlossmann and Prof. Dr. Thomas Hehlgans
Date of exam:8 March 2012
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Interdisciplinary Subject Network:Not selected
Keywords:Pharmakologie, Histamin, G-Protein-gekoppelte Rezeptoren
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited on:20 Mar 2012 11:26
Last modified:13 Mar 2014 18:42
Item ID:23555
Owner only: item control page


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