Schlegel, Birgit and Laggner, Christian and Meier, Rene and Langer, Thierry and Schnell, David and Seifert, Roland and Stark, Holger and Höltje, Hans-Dieter and Sippl, Wolfgang
Generation of a homology model of the human histamine H₃ receptor for ligand docking and pharmacophore-based screening.
Journal of Computer-Aided Molecular Design.
at publisher (via DOI)
The human histamine H₃ receptor (hH₃R) is a G-protein coupled receptor (GPCR), which modulates the release of various neurotransmitters in the central and peripheral nervous system and therefore is a potential target in the therapy of numerous diseases. Although ligands addressing this receptor are already known, the discovery of alternative lead structures represents an important goal in drug ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy|
|Keywords:||Histamine; H₃ receptor; Docking; Molecular dynamics; GOLD; Catalyst; Pharmacophore; Rhodopsin|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||28 Jan 2008 15:13|
|Last Modified:||13 Mar 2014 10:20|