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Generation of a homology model of the human histamine H₃ receptor for ligand docking and pharmacophore-based screening

Schlegel, Birgit and Laggner, Christian and Meier, Rene and Langer, Thierry and Schnell, David and Seifert, Roland and Stark, Holger and Höltje, Hans-Dieter and Sippl, Wolfgang (2007) Generation of a homology model of the human histamine H₃ receptor for ligand docking and pharmacophore-based screening. Journal of Computer-Aided Molecular Design.

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Abstract

The human histamine H₃ receptor (hH₃R) is a G-protein coupled receptor (GPCR), which modulates the release of various neurotransmitters in the central and peripheral nervous system and therefore is a potential target in the therapy of numerous diseases. Although ligands addressing this receptor are already known, the discovery of alternative lead structures represents an important goal in drug ...

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Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Identification Number:
ValueType
10.1007/s10822-007-9127-xDOI
Keywords:Histamine; H₃ receptor; Docking; Molecular dynamics; GOLD; Catalyst; Pharmacophore; Rhodopsin
Subjects:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:28 Jan 2008 15:13
Last Modified:13 Mar 2014 10:20
Item ID:2664
Owner Only: item control page
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