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Number of items at this level: 202.

2014

Haunschild, Gundula (2014) Nachweis und molekulare Charakterisierung EpCAM-positiver Zellen im Knochenmark von Mammakarzinom-Patientinnen. PhD, Universität Regensburg

Schramm, Andrea (2014) Analyse renaler Funktionen der cGMP-abhängigen Proteinkinase II. PhD, Universität Regensburg

2013

Kees, Martin Georg and Schaeftlein, André and Haeberle, Helene Anna and Kees, Frieder K. and Kloft, Charlotte and Heininger, Alexandra (2013) Population pharmacokinetics and pharmacodynamic evaluation of intravenous and enteral moxifloxacin in surgical intensive care unit patients. The Journal of antimicrobial chemotherapy.

Chen, W. and Oberwinkler, H. and Werner, F. and Gaßner, B. and Nakagawa, H, and Feil, R. and Hofmann, F. and Schlossmann, Jens and Dietrich, A. and Gudermann, T. and Nishida, M. and Del Galdo, S. and Wieland, T. and Kuhn, M. (2013) ANP-mediated inhibition of microcirculatory endothelial Ca 2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels. Arteriosclerosis, Thrombosis, and Vascular Biology 33 (9), pp. 2121-2129. (In Press)

Dietrich, P. and Moleda, Lukas and Kees, Frieder K. and Müller, M. and Straub, R. H. and Hellerbrand, C. and Wiest, R. (2013) Dysbalance in sympathetic neurotransmitter release and action in cirrhotic rats: impact of exogenous neuropeptide Y. Journal of hepatology 58 (2), pp. 254-261.

Schlossmann, Jens (2013) Editorial of the Special issue: signalling molecules and Signal transduction in cells. Int. J. Mol. Sci. 14, 1-x, doi:103390/ijms140x000x 14 (6), pp. 11438-11443.

Salb, Katharina and Schlossmann, Jens (2013) Methods for identification of cGKI substrates. In: UNSPECIFIED Methods in Molecular Biology, 1020. Methods in Molecular Biology, pp. 147-162.

Schinner, E. and Schramm, A. and Kees, F. and Hofmann, F. and Schlossmann, Jens (2013) Suppression of kidney fibrosis by cGMP-dependent protein Kinase Ia. Kidney International. (In Press)

Wolfertstetter, Stefanie and Huettner, Johannes Philip and Schlossmann, Jens (2013) cGMP-dependent Protein Kinase Inhibitors in Health and Disease. Pharmaceuticals 6, pp. 269-286.

2012

Hieke, Bernhard (2012) Bedeutung von IRAG für die Calciumregulation im glatten Muskel. PhD, Universität Regensburg

Salb, Katharina (2012) Funktion von IRAG für cGMP-Kinase-I-Komplexe sowie für die InsP3R-I-Phosphorylierung. PhD, Universität Regensburg

Peter, Katrin (2012) Einfluss der Tumormetaboliten 5'-Deoxy-5'-Methylthioadenosin und Milchsäure auf humane Monozyten. PhD, Universität Regensburg

Deml, Karl-Friedrich (2012) Interaktionen von Histamin H1-Rezeptoragonisten und
–antagonisten mit dem humanen Histamin H4-Rezeptor.
PhD, Universität Regensburg

Schlossmann, Jens and Schinner, E. (2012) cGMP becomes a drug target. Naunyn Schmiedeberg´s Archives of Pharmacology 385 (3), pp. 243-252.

Doser, Kristina (2012) Untersuchungen zur B-Zell-Rekonstitution nach allogener Stammzelltransplantation. PhD, Universität Regensburg

Rupprecht, Korbinian (2012) Einfluss von Pantoprazol auf die Bioverfügbarkeit von Mycophenolsäure aus CellCept® bzw. myfortic®: Pharmakokinetische Untersuchungen in vitro und an Probanden. PhD, Universität Regensburg

Salb, Katharina and Schinner, Elisabeth and Schlossmann, Jens (2012) Identification of cGMP-Kinase complexes by affinity chromatography. In: INTECH Chapter in Affinity Chromatography. UNSPECIFIED, pp. 255-272. ISBN 978-953-51-0325-7.

Taha, Hesham and Dove, Stefan and Geduhn, Jens and König, Burkhard and Shen, Yuequan and Tang, Wei-Jen and Seifert, Roland (2012) Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 monoand bis-(M)ANT-substituted nucleoside 5′-triphosphates. Naunyn-Schmiedeberg's Archives of Pharmacology (385), pp. 57-68.

Kees, Martin G. and Steinke, T. and Moritz, S. and Rupprecht, K. and Paulus, E. M. and Kees, Frieder K. and Bucher, M. and Faerber, L. (2012) Omeprazole impairs the absorption of mycophenolate mofetil but not of enteric-coated mycophenolate sodium in healthy volunteers. Journal of clinical pharmacology 52 (8), pp. 1265-1272.

Justinger, Christoph and Schilling, Martin K. and Kees, Martin G. and Kauffels, Anne and Hirschmann, Katrin and Kopp, Berit and Kees, Frieder K. and Kollmar, Otto (2012) Penetration of moxifloxacin into liver tissue. International journal of antimicrobial agents 39 (6), pp. 505-509.

Luo, C. and Gangadharan, V. and Bali, K.K. and Xie, R.G. and Agarwal, N. and Kurejova, M. and Tappe-Theodor, A. and Tegeder, I. and Feil, S. and Lewin, G. and Polgar, E. and Todd, A.J. and Schlossmann, Jens and Hofmann, F. and Liu, D.L. and Hu, S.J. and Feil, R. and Kuner, T. and Kuner, R. (2012) Presynaptically localized cyclic GMP-dependent Protein Kinase I is a key determinant of spinal potentiation and pain hypersensitivity. PLoS Biology 10 (3), 1e1001283.

Jaumann, M. and Dettling, J. and Gubelt, M. and Zimmermann, U. and Gerling, A. and Paquet-Durand , F. and Feil, S. and Wolpert, S. and Franz, C. and Varakina, K. and Xiong, H. and Brandt, N. and Kuhn, S. and Geisler, H.-S. and Rohbock, K. and Ruth, P. and Schlossmann, Jens and Hütter, J. and Sandner, P. and Feil, R. and Engel, J. and Knipper, M. and Rüttiger, L. (2012) cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and heraring function. Nature Medicine 18, pp. 252-259.

2011

Hübner, Melanie and Dixit, A. and Mou, T.-C. and Lushington, Gerald H. and Pinto, Cibele S. and Gille, A. and Geduhn, Jens and König, Burkhard and Sprang, S. R. and Seifert, Roland (2011) Structural Basis for the High-Affinity Inhibition of Mammalian Membranous Adenylyl Cyclase by 2`,3`-O-(N-Methylanthraniloyl)-Inosine 5`-Triphosphate. Molecular Pharmacology 80 (1), pp. 87-96.

Schinner, Elisabeth (2011) Funktionelle Studie der NO/cGMP Signalkaskade in Niere und Thrombozyten. PhD, Universität Regensburg

Erdorf, Miriam and Seifert, Roland (2011) Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (4), pp. 357-372.

Kellermann, K. and Dertinger, N. and Blobner, M. and Kees, Frieder and Kochs, E. F. and Jungwirt, B. (2011) Perioperative moxifloxacin treatment in rats subjected to deep hypothermic circulatory arrest: reduction in cerebral inflammation but without improvement in cognitive performance. Journal of Thoracic and Cardiovascular Surgery 141 (3), pp. 796-802.

Schnell, David and Brunskole, Irena and Ladova, Katerina and Schneider, Erich H. and Igel, Patrick and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), pp. 457-470.

Geduhn, Jens and Dove, Stefan and Shen, Yuequan and Tang, Wei-Jen and König, Burkhard and Seifert, Roland (2011) Bis-Halogen-Anthraniloyl-Substituted Nucleoside 5'-triphosphates as Potent and Selective Inhibitors of Bordetella pertussis CyaA. The Journal of pharmacology and experimental therapeutics 336 (1), pp. 104-115.

Schinner, Elisabeth and Salb, Katharina and Schlossmann, Jens (2011) Signaling via IRAG is essential for NO/cGMP-dependent inhibition of platelet activitation. Platelets.

Salb, Katharina and Schinner, Elisabeth and Schlossmann, Jens (2011) Function of IRAG and the phosphorylation of the InsP3R-I for the NO/cGMP-dependent inhibition of platelet aggregation. BMC Pharmacology (11), P58.

Schlossmann, Jens and Desch, M. (2011) IRAG and Novel PKG Targeting in the cardiovascular system. American Journal of Physiology- Heart und Circulatory Physiology 301, H672-682.

Ertl, C. and Lukowski, R. and Sigl, K and Schlossmann, Jens and Hofmann, F. and Wegener, Jörg W. (2011) Kinetics of relaxation by cGMP/cGKI signaling in fundus smooth muscle. Eur J Pharmacol 670 (1), pp. 266-271.

Kees, Martin G. and Weber, Susanne and Kees, Frieder K. and Horbach, Thomas (2011) Pharmacokinetics of moxifloxacin in plasma and tissue of morbidly obese patients. The Journal of antimicrobial chemotherapy 66 (10), pp. 2330-2335.

Pinto, Cibele S. and Lushington, Gerald H. and Richter, M. and Gille, A. and Geduhn, Jens and König, Burkhard and Mou, T.-C. and Sprang, S. R. and Seifert, Roland (2011) Structure–activity relationships for the interactions of 2`- and 3`-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases. Biochemical Pharmacology 82 (4), pp. 358-370.

Werder, A. and Mayr, M. and Schneider, G. and Oesterle, D. and Fritsch, R. M. and Seidler, B. and Schlossmann, Jens and Hofmann, F. and Schemann, M. and Allescher, H. D. and Schmid, R.M. and Saur, D. (2011) Truncated IRAG variants modulate cGMP-mediated inhibition of human colonic smooth muscle cell contraction. American Journal of Physiology - Cell Physiology : Am J Physiol Cell Physiol 301 (6), C1445-1457.

2010

Kees, MG and Hilpert, JW and Gnewuch, C and Kees, F. and Voegeler, S. (2010) Clearance of vancomycin during continuous infusion in intensive care unit patients: correlation with measured and estimated creatinine clearance and serum cystatin C. International Journal of Antimicrobial Agents 36 (6), pp. 545-548.

Appl, Heidrun (2010) Molecular analysis of the interaction of the four histamine receptor subtypes with antidepressant and antipsychotic drugs. PhD, Universität Regensburg

Schnell, David and Strasser, Andrea and Seifert, Roland (2010) Comparison of the pharmacological properties of human and rat histamine H(3)-receptors. Biochemical Pharmacology 80 (9), pp. 1437-1449.

Erdorf, Miriam (2010) Regulation of mammalian membranous adenylyl cyclases by diterpenes and MANT-nucleotides. PhD, Universität Regensburg

Desch, Matthias (2010) Funktionelle Charakterisierung des cGMP-abhängigen Proteinkinase-Substrates IRAG und des potentiellen "second messenger" zyklisches Cytidin-3',5'-monophosphat im glatten Muskel. PhD, Universität Regensburg

Hübner, Melanie (2010) Crystal structure of the catalytic domains of membranous adenylyl cyclase with MANT-ITP and electrophysiological analysis of MANT nucleotides in cardiomyocytes. PhD, Universität Regensburg

Mathar, I. and Vennekens, R. and Meissner, M. and Kees, Frieder K. and Van der Mieren , G. and Camacho Londono, J. (2010) Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. The Journal of Clinical Investigation 120 (9), pp. 3267-3279.

Desch, Matthias and Schinner, Elisabeth and Kees, Frieder K. and Hofmann, F. and Seifert, Roland and Schlossmann, Jens (2010) Cyclic cytidine 3´,5´-monophosphate (cCMP) signals via cGMP kinase I. FEBS Letters 584 (18), pp. 3979-3984.

Schneider, E. H. and Strasser, Andrea and Thurmond, R. L. and Seifert, Roland (2010) Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands. Journal of Pharmacology and Experimental Therapeutics 334 (2), pp. 513-521.

Spangler, Corinna (2010) Molecular and cellular analysis of the "adenylyl cyclase" exotoxins from Bacillus anthracis and Bordetella pertussis. PhD, Universität Regensburg

Desch, Matthias and Sigl, K. and Hieke, Bernhard and Salb, Katharina and Kees, F. and Bernhard, D. (2010) IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation. Cardiovascular Research 86 (3), pp. 496-505.

Weitl, Nina (2010) Interaktionen des humanen β1- und β2- Adrenorezeptors mit Isoproterenol, Epinephrin, Norepinephrin und Dopamin. PhD, Universität Regensburg

Schnell, David and Seifert, Roland (2010) Modulation of Histamine H(3) receptor function by monovalent ions. Neuroscience Letters 472 (2), pp. 114-118.

Schnell, David and Burleigh, Katrina and Seifert, Roland and Trick, Jonathan (2010) No evidence for functional selectivity of proxyfan at the human histamine H3 receptor coupled to defined Gi/Go protein heterotrimers. Journal of Pharmacology and Experimental Therapeutics . JPET 332 (3), pp. 996-1005.

Schnell, David (2010) Molecular analysis of the histamine H3-receptor. PhD, Universität Regensburg

Schilling, Elmar (2010) Analysis of tissue-specific & allele-specific DNA methylation. PhD, Universität Regensburg

Mohammed, Hesham Hamada Taha (2010) Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin. PhD, Universität Regensburg

Göttle, Martin and Dove, Stefan and Kees, Frieder K. and Schlossmann, Jens and Geduhn, Jens and König, Burkhard and Shen , Y. and Tang, W. J. and Kaever, V. and Seifert, Roland (2010) Citidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA. Biochemistry 49, pp. 5494-5503.

Desch, M. and Sigl, K. and Hieke, B. and Salb, Katharina and Kees, Frieder and Bernhard, D. and Jochim , A. and Spiessberger, B. and Höcherl, K. and Feil, R. and Lukowski, R. and Wegener, Jörg W. and Hofmann, F. and Schlossmann, Jens (2010) IRAG determines NO- and ANP-mediated smooth muscle relaxation. Cardiovascular Research 86 (3), pp. 496-505.

Schneider, Erich H. and Schnell, David and Strasser, Andrea and Dove, Stefan and Seifert, Roland (2010) Impact of the DRY Motif and the Missing "Ionic Lock" on Constitutive Activity and G-Protein Coupling of the Human Histamine H-4 Receptor. Journal of Pharmacology and Experimental Therapeutics 333 (2), pp. 382-392.

Schneider, Erich and Schnell, David and Strasser, Andrea and Dove, Stefan and Seifert, Roland (2010) Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor. J Pharmacol Exp Ther : The journal of pharmacology and experimental therapeutics 333 (2), pp. 382-392.

2009

Jouma, Louay (2009) Functional analysis of the mouse histamine H4 receptor in myeloid cells. PhD, Universität Regensburg

Igel, Patrick and Geyer, Roland and Straßer, Andrea and Dove, Stefan and Seifert, Roland and Buschauer, Armin (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists. Journal of Medicinal Chemistry 52 (20), pp. 6297-6313.

Ratzinger, Sabine (2009) Studies on the molecular interactions of collagen type XVI.
Part I: The role of collagen XVI in pathological disorders
Part II: Extablishment of a retroviral mediated gene silencing model.
PhD, Universität Regensburg

Göttle, Martin (2009) Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins. PhD, Universität Regensburg

Igel, Patrick and Schneider, Erich and Schnell, David and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2009) N(G)-Acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent. Journal of Medicinal Chemistry 52 (8), pp. 2623-2627.

Kraus, Anja and Ghorai, Prasanta and Birnkammer, Tobias and Schnell, David and Elz, Sigurd and Seifert, Roland and Dove, Stefan and Bernhardt, Günther and Buschauer, Armin (2009) N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists. ChemMedChem 4 (2), pp. 232-240.

Igel, Patrick and Schnell, David and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2009) Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand. ChemMedChem 4 (2), pp. 225-231.

Frei, E. and Huster, M. and Smital, P. and Schlossmann, Jens and Hofmann, F. and Wegener, Jörg W. (2009) Calcium-dependent and Calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle. American Journal of Physiology 297, G834-839.

Seifert, Roland and Dove, Stefan (2009) Functional Selectivity of GPCR Ligand Stereoisomers: New Pharmacological Opportunities. Mol. Pharmacol. 75 (1), pp. 13-18.

Deml, Karl-Friedrich and Beermann , S and Neumann, Detlef and Strasser, Andrea and Seifert, Roland (2009) Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor. Mol Pharmacol : Molecular pharmacology 76 (5), pp. 1019-1030.

Taha, H. M. and Schmidt, J. and Göttle, M. and Suryanarayana, S. and Shen, Y. and Tang, W.-J. and Gille, A. and Geduhn, Jens and König, Burkhard and Dove, Stefan and Seifert, Roland (2009) Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides. Mol. Pharmacol. 75 (3), pp. 693-703.

Egger, Michael and Maity, Prantik and Hübner, Melanie and Seifert, Roland and König, Burkhard (2009) Synthesis and pharmacological properties of new tetracyclic forskolin analogues. European Journal of Organic Chemistry 2009 (21), pp. 3613-3618.

Schlossmann, Jens and Desch, M. (2009) cGK substrates. Handbook of Experimental Pharmacology 191, pp. 163-193.

2008

Ghorai, Prasanta and Kraus, Anja and Keller, Max and Götte, Carsten and Igel, Patrick and Schneider, Erich and Schnell, David and Bernhardt, Günther and Dove, Stefan and Zabel, Manfred and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), pp. 7193-7204.

Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2008) Frontiers in medicinal chemistry in Regensburg. ChemMedChem 3 (8), pp. 1181-1184.

Schlossmann, Jens and Hofmann, F. (2008) Receptor mediated mechanisms. In: Greim, H. and Snyder, R., (eds.) Toxicology and risk assessment : a comprehensive introduction. Wiley, Chicester. ISBN 978-0-470-86893-5.

Schmidtko, A. and Gao , W. and König, P. and Heine, S. and Motterlini, R. and Ruth, P. and Schlossmann, Jens and Koesling, D. and Niederberger, E. and Tegeder, I. and Friebe, A. and Geisslinger, G. (2008) cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. Journal of Neuroscience 28, pp. 8568-8576.

2007

Göttle, Martin and Dove, Stefan and Steindel, Phillip and Shen, Yuequan and Tang, Wei-Jen and Geduhn, Jens and König, Burkhard and Seifert, Roland (2007) Molecular Analysis of the Interaction of Bordetella pertussis Adenylyl Cyclase with Fluorescent Nucleotides. Molecular Pharmacology 72 (3), pp. 526-535.

Lorenz, Veronika and Pinto, Cibele S. and Seifert, Roland (2007) Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency. Neuroscience Letters 420 (1), pp. 6-11.

Wang, Jenna L. and Guo, Jian-Xin and Zhang, Qi-Yuan and Wu, Jay J.-Q. and Seifert, Roland and Lushington, Gerald H. (2007) A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified
and unmodified nucleotide inhibitors.
Bioorganic & Medicinal Chemistry 15 (8), pp. 2993-3002.

Preuss, Hendrik and Ghorai, Prasanta and Kraus, Anja and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2007) Constitutive Activity and Ligand Selectivity of Human,
Guinea Pig, Rat, and Canine Histamine H₂ Receptors.
Journal of Pharmacology and Experimental Therapeutics 321 (3), pp. 983-995.

Preuss, Hendrik and Ghorai, Prasanta and Kraus, Anja and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2007) Mutations of Cys-17 and Ala-271 in the Human Histamine H₂
Receptor Determine the Species Selectivity of Guanidine-Type Agonists and Increase Constitutive Activity.
Journal of Pharmacology and Experimental Therapeutics 321 (3), pp. 975-982.

Xie, Sheng-Xue and Schalkhausser, Fabian and Ye, Qi-Zhuang and Seifert, Roland and Buschauer, Armin (2007) Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors. Archiv der Pharmazie 340 (1), pp. 9-16.

Rottlaender, Dennis and Matthes, Jan and Vatner, Stephen F. and Seifert, Roland and Herzig, Stefan (2007) Functional Adenylyl Cyclase Inhibition in Murine
Cardiomyocytes by 2'(3')-O-(N-Methylanthraniloyl)-Guanosine
5'-[γ-Thio]triphosphate.
Journal of Pharmacology and Experimental Therapeutics 321 (2), pp. 608-615.

Antl, M. and von Brühl, M. L. and Eigslperger, C. and Werner, M. and Konrad, I. and Köcher, T. and Wilm, M. and Hofmann, F. and Massberg, S. and Schlossmann, Jens (2007) IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood 109, pp. 552-559.

Kees, F. and Bucher, M. and Schweda, F. and Gschaidmeier, H. and Faerber, L. and Seifert, R. (2007) Neoimmun versus Neoral: a bioequivalence study in healthy volunteers and influence of a fat-rich meal on the bioavailability of Neoimmun. Naunyn-Schmiedeberg's Archives of Pharmacology 375 (6), pp. 393-399.

Preuss, Hendrik and Ghorai, Prasanta and Kraus, Anja and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2007) Point Mutations in the Second Extracellular Loop of the Histamine H2 Receptor do not affect the Species-Selective Activity of Guanidine-Type Agonists. Naunyn Schmiedebergs Arch. Pharmacol. 376 (4), pp. 253-264.

Sausbier, M. and Zhou, X.B. and Beier, C. and Sausbier, U. and Wolpers , D. and Maget, S. and Martin, C. and Dietrich, A. and Ressmeyer, A.R. and Schlossmann, Jens and Hofmann, F. and Neuhuber, W. and Gudermann, T. and Uhlig, S. and Korth, M. and Ruth, P. (2007) Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+channel. FASEB Journal 21, pp. 812-822.

Weber, S. and Bernhard, D. and Lukowski, R. and Weinmeister, P. and Wörner, R. and Wegener, J. W. and Valtcheva, N. and Feils, S. and Schlossmann, Jens and Hofmann, F. and Feil, R. (2007) Rescue of cGMP Kinase I knockout mice by smooth muscle specific expression of either isozyme. Circulation Research 101, pp. 1096-1103.

2006

Kees, Frieder and Bucher, Michael and Schweda, Frank and Gschaidmeier, Harald and Burhenne, Juergen and Mikus, Gerd and Faerber, Lothar (2006) Comparative bioavailability of the microemulsion formulation of cyclosporine (Neoral) with a generic dispersion formulation (Cicloral) in young healthy male volunteers. Therapeutic drug monitoring 28 (3), pp. 312-320.

Xie, Sheng-Xue and Kraus, Anja and Ghorai, Prasanta and Ye, Qi-Zhuang and Elz, Sigurd and Buschauer, Armin and Seifert, Roland (2006) N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-
yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2- Receptors.
Journal of Pharmacology and Experimental Therapeutics 317 (3), pp. 1262-1268.

Xie, Sheng-Xue and Ghorai, Prasanta and Ye, Qi-Zhuang and Buschauer, Armin and Seifert, Roland (2006) Probing Ligand-Specific Histamine H1- and H2-Receptor
Conformations with NG-Acylated Imidazolylpropylguanidines.
The Journal of Pharmacology and Experimental Therapeutics 317 (1), pp. 139-146.

Pinto, Cibele S. and Seifert, Roland (2006) Decreased GTP-stimulated adenylyl cyclase activity in
HPRT-deficient human and mouse fibroblast and rat
B103 neuroblastoma cell membranes.
Journal of Neurochemistry 96 (2), pp. 454-459.

Hofmann, F. and Feil, R. and Kleppisch, T. and Schlossmann, Jens (2006) Function of cGMP-dependent Protein Kinase as revealed by gene deletion. Physiological Reviews 86, pp. 1-23.

2005

Feil, S. and Zimmermann, P. and Knorn, A. and Brummer, S. and Schlossmann, Jens and Hofmann, F. and Feil, R. (2005) Distribution of cGMP-dependent protein kinase type 1 and its isoforms in the mouse brain and retina. Neuroscience 135, pp. 863-868.

Schlossmann, Jens and Feil, R. and Hofmann, F. (2005) Insights into cGMP signaling derived from cGMP Kinase knockout mice. Frontiers in Bioscience 10, pp. 1279-1289.

Werner, C.G. and Godrey, V. and Arnold, R.R. and Featherstone, G.L. and Bender, D. and Schlossmann, Jens and Schiemann, M. and Hofmann, F. and Pryzwansky, K.B. (2005) Neutrophil dysfunction in guanosine 3',5'-cyclic monophosphate-dependent protein kinase I-deficient mice. Journal of Immunology 175, pp. 1919-1929.

Schlossmann, Jens and Hofmann, F. (2005) cGMP-dependent protein kinases in drug discovery. Drug Discovery Today 10, pp. 627-634.

2004

Geiselhöringer, A. and Gaisa, M. and Hofmann, F. and Schlossmann, Jens (2004) Distribution of IRAG and cGKI-isoforms in murine tissues. FEBS Letters 575, pp. 19-22.

Geiselhöringer, A. and Werner, M. and Sigl, K. and Smital, P. and Wörner, R. and Acheo, L. and Stieber, J. and Weinmeister, P. and Feil, R. and Feil, S. and Wegener, J. and Hofmann, F. and Schlossmann, Jens (2004) IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP Kinase. EMBO Journal 23, pp. 4222-4231.

Fritsch, R.M. and Saur, D. and Kurjak , M. and Oesterle, D. and Schlossmann, Jens and Geiselhöringer, A. and Hofmann, F. and Allescher, H.D. (2004) InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle. J. Biol. Chem. 279, pp. 12551-12559.

Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954.

2003

Koller, A. and Schlossmann, Jens and Ashman, K. and Uttenweiler-Joseph, S. and Ruth, P. l. and Hofmann, F. (2003) Association of phospholamban with a cGMP kinase signaling complex. Biochemical and Biophysical Research Communications : Biochem. Biophys. Res. Commun. 300, pp. 155-160.

Seifert, Roland and Wenzel-Seifert, Katharina and Bürckstümmer, Tilmann and Pertz, Heinz H. and Schunack, Walter and Dove, Stefan and Buschauer, Armin and Elz, Sigurd (2003) Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,. Journal of Pharmacology and Experimental Therapeutics 305, pp. 1104-1115.

Schlossmann, Jens and Feil, R. and Hofmann, F. (2003) Signaling through NO and cGMP-dependent protein kinases. Annals of Medicine 35, pp. 21-27.

2002

Feil, R. and Gappa, N. and Rutz, M. and Schlossmann, Jens and Rose, C.R. and Konnerth, A. and Brummer, S. and Hofmann, F. (2002) Functional Reconstitution of vascular smooth muscle cells with cGMP-dependent protein kinase I isoforms. Circulation Research : Circ. Res. 90, pp. 1080-1086.

2001

Kelley, Melissa T. and Bürckstümmer, Tilmann and Wenzel-Seifert, Katharina and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2001) Distinct interaction of human and guinea pig histamine H_2-Receptor with guanidine-type agonists,. Molecular Pharmacology 60 (6), pp. 1210-1225.

Ammendola, A. and Geiselhöringer, A. and Hofmann, F. and Schlossmann, Jens (2001) Molecular Determinants of the Interaction between the Inositol 1,4,5-Trisphosphate Receptor-associated cGMP Kinase Substrate (IRAG) and cGMP Kinase Iβ. J. Biol. Chem. 276, pp. 24153-24159.

Wenzel-Seifert, Katharina and Kelley, Melissa T. and Buschauer, Armin and Seifert, Roland (2001) Similar apparent constitutive activity of human histamine H_2-receptor fused to long and short splice variants of Gsa,. Journal of Pharmacology and Experimental Therapeutics 299 (3), pp. 1013-1020.

2000

Schlossmann, Jens and Ammendola, A. and Ashman, K. and Zong, X and Huber, A. and Neubauer, G. and Wang, G. X. and Allescher, H. D. and Korth, M. and Wilm, M. and Hofmann, F. and Ruth, P. (2000) Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Nature 404, pp. 197-201.

Hofmann, F. and Ammendola, A. and Schlossmann, Jens (2000) Rising behind NO: cGMP-dependent protein kinases. Journal of cell science : J. Cell Sci. 113, pp. 1671-1676.

1999

Gaburjakova, M. and Schlossmann, Jens and Ondrias, K. (1999) Properties of a new calcium-permeable single channel from tracheal microsomes. Biochimica et Biophysica Acta : BBA. Biomembranes 1417, pp. 25-31.

1998

Zhou, X.B. and Schlossmann, Jens and Hofmann, F. and Ruth, P. and Korth, M. (1998) Regulation of stably expressed and native BK channels from human myometrium by cGMP- and cAMP-dependent protein kinase. Pflügers Archiv : European journal of physiology 436, pp. 725-734.

1996

Zhou , X. B. and Ruth, P. and Schlossmann, Jens and Hofmann, F. and Korth, M. (1996) Protein Phosphatase 2A Is Essential for the Activation of Ca2+-activated K+ Currents by cGMP-dependent Protein Kinase in Tracheal Smooth Muscle and Chinese Hamster Ovary Cells. Journal of Biological Chemistry : J. Biol Chem 271, pp. 19760-19767.

Schlossmann, Jens and Lill, R. and Neupert, W. and Court, D. A. (1996) Tom71, a novel homologue of the mitochondrial preprotein receptor Tom70. The journal of biological chemistry : J. Biol. Chem. 271, pp. 17890-17895.

1995

Schlossmann, Jens and Neupert, W. (1995) Assembly of the preprotein receptor MOM72/MAS70 into the protein import complex of the outer membrane of mitochondria. J. Biol Chem 270, pp. 27116-27121.

Hagelüken, Astrid and Burde, Rahel and Nürnberg, Bern and Harhammer, R. and Buschauer, Armin and Seifert, Roland (1995) Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism. Naunyn Schmiedeberg's Arch. Pharmacol. 351, pp. 305-308.

1994

Klinker, J. F. and Schwaner, I. and Offermanns, S. and Hagelüken, A. and Seifert, Roland (1994) Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants. Biochemical pharmacology 48 (10), pp. 1857-1864.

Wenzel-Seifert, K. and Schächtele, C. and Hummel, R. and Grünbaum, L. and Seifert, Roland (1994) Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C. Biochemical pharmacology 48 (5), pp. 859-864.

Seifert, Roland and Grünbaum, L. and Schultz, Günter (1994) Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores. Naunyn-Schmiedeberg's archives of pharmacology 349 (4), pp. 355-361.

Musgrave, I. F. and Seifert, Roland (1994) Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors. Biochemical pharmacology 47 (2), pp. 233-239.

Hagelüken, A. and Grünbaum, L. and Nürnberg, B. and Harhammer, R. and Schunack, W. and Seifert, Roland (1994) Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins. Biochemical pharmacology 47 (10), pp. 1789-1795.

Musgrave, I. F. and Seifert, Roland and Schultz, Günter (1994) Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells. The Biochemical journal 301 ( Pt 2, pp. 437-441.

Klinker, J. F. and Hagelüken, A. and Grünbaum, L. and Heilmann, I. and Nürnberg, B. and Harhammer, R. and Offermanns, S. and Schwaner, I. and Ervens, J and Wenzel-Seifert, K and Müller, T. and Seifert, Roland (1994) Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase. The Biochemical journal 304 ( Pt 2, pp. 377-383.

Wenzel-Seifert, K. and Schächtele, C. and Seifert, Roland (1994) N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions. Biochemical and biophysical research communications 200 (3), pp. 1536-1543.

Naim, M. and Seifert, Roland and Nürnberg, B. and Grünbaum, L. and Schultz, Günter (1994) Some taste substances are direct activators of G-proteins. The Biochemical journal 297 ( Pt 3, pp. 451-454.

Schlossmann, Jens and Dietmeier, K. and Pfanner, N. and Neupert, W. (1994) Specific recognition of mitochondrial preproteins by the cytosolic domain of the import receptor MOM72. The journal of biological chemistry : J. Biol.Chem. 269, pp. 11893-11901.

Berger, M. and Offermanns, S. and Seifert, Roland and Schultz, Günter (1994) Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets. The American journal of physiology 266 (6 Pt 1), C1684-C1691.

Seifert, Roland and Hagelüken, A. and Höer, A. and Höer, D. and Grünbaum, L. and Offermanns, S. and Schwaner, I. and Zingel, V. and Schunack, W. and Schultz, Günter (1994) The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes. Molecular Pharmacology 45 (4), pp. 578-586.

Tsang, K. W. and Roberts, P. and Read, R. C. and Kees, Frieder and Wilson, R. and Cole, P. J. (1994) The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration. The Journal of antimicrobial chemotherapy 33 (2), pp. 289-297.

Honeybourne, D. and Kees, Frieder K. and Andrews, J. M. and Baldwin, D. and Wise, R. (1994) The levels of clarithromycin and its 14-hydroxy metabolite in the lung. The European respiratory journal 7 (7), pp. 1275-1280.

1993

Sedlmayr, T. and Petersen, F. and Raasch, W. and Kees, Frieder K. (1993) Clarithromycin, ein neues Makrolid-Antibiotikum. Wirksamkeit bei puerperalen Infektionen und Übertritt in die Muttermilch [Clarithromycin, a new macrolide antibiotic. Effectiveness in puerperal infections and pharmacokinetics in breast milk]. Geburtshilfe und Frauenheilkunde 53 (7), pp. 488-491.

Wenzel-Seifert, Katharina and Seifert, Roland (1993) Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. The Journal of Immunology 150 (10), pp. 4591-4599.

Klinker, J. F. and Höer, A. and Schwaner, I. and Offermanns, S. and Wenzel-Seifert, Katharina and Seifert, Roland (1993) Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. The Biochemical journaL 296 ( Pt 1, pp. 245-251.

Wenzel-Seifert, Katharina and Seifert, Roland (1993) Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations. Naunyn-Schmiedeberg's archives of pharmacology 348 (1), pp. 7-13.

Grobecker, H. F. and Kees, Frieder K. (1993) Pharmacokinetic parameters and haemodynamic actions of midodrine in young volunteers. International angiology : a journal of the International Union of Angiology 12 (2), pp. 119-124.

Musgrave, I. F. and Genieser, H. G. and Maronde, E. and Seifert, Roland (1993) Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine. FEBS letters 318 (3), pp. 227-230.

Dietmeier, K. and Zara, V. and Voos, W. and Schlossmann, Jens and Moczko, M. and Pfanner, N. (1993) Targeting and translocation of the phosphate carrier/p32 to the inner membrane of yeast mitochondria. The journal of biological chemistry : J. Biol. Chem. 268, pp. 25958-25964.

1992

Dominiak, P. and Kees, Frieder K. and Welzel, D. and Grobecker, H. (1992) Cardiovascular parameters and catecholamines in volunteers during passive orthostasis. Influence of antihypotensive drugs. Arzneimittel-Forschung 42 (5), pp. 637-642.

Krautwurst, D. and Seifert, Roland and Hescheler, J. and Schultz, Günter (1992) Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production. The Biochemical journal 288 ( Pt 3, pp. 1025-1035.

Klinz, F. J. and Seifert, Roland and Schwaner, I. and Gausepohl, H. and Frank, R. and Schultz, Günter (1992) Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells. European journal of biochemistry 207 (1), pp. 207-213.

Seifert, Roland and Höer, Ariane and Offermann, Stefan and Buschauer, Armin and Schunack, Walter (1992) Histamine increases Ca^2+ in dibutyryl cyclic AMP-differentiated HL-60 cells via H_1-receptors and is an incomplete secretagogue. Mol. Pharmacol. 42, pp. 227-234.

Seifert, Roland and Höer, Ariane and Schwaner, Ingo and Buschauer, Armin (1992) Histamine increases cytosolic Ca^2+ in HL-60 promyelocytes predominantly via H_2-receptors with an unique agonist/antagonist profile and induces functional differentiation. Molecular Pharmacology 42, pp. 235-241.

Seifert, Roland and Serke, S. and Huhn, D. and Bessler, W. G. and Hauschildt, S. and Metzger, J. and Wismüller, K. H. and Jung, G. (1992) Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation. European journal of biochemistry / FEBS 203 (1-2), pp. 143-151.

Offermanns, S. and Seifert, Roland and Metzger, J. W. and Jung, G. and Lieberknecht, A. and Schmidt, U. and Schultz, Günter (1992) Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochemical Journal 282 ( Pt 2, pp. 551-7.

Söllner, T. and Rassow, J. and Wiedmann, T. and Schlossmann, Jens and Neupert, W. and Pfanner, N. (1992) Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates. Nature 355, pp. 84-87.

Ervens, J. and Seifert, Roland (1992) Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism. Biochemical pharmacology 44 (4), pp. 637-644.

Kees, Frieder K. (1992) Orale Cephalosporine [Oral cephalosporins]. Medizinische Monatsschrift für Pharmazeuten 15 (1), pp. 2-10.

Schwaner, I. and Seifert, Roland and Schultz, Günter (1992) Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways. The Biochemical journal 281 ( Pt 2, pp. 301-307.

Kees, Frieder K. and Raasch, W. and Grobecker, H.F. (1992) Strukturelle Charakterisierung eines unbekannten Metaboliten von Ciprofloxacin [Structural characterization of an unknown metabolite of ciprofloxacin]. Arzneimittel-Forschung 42 (4), pp. 570-575.

Keil, P. and Schlossmann, Jens and Pfanner, N. (1992) Targeting und translocation of mitochondrial precursor proteins. Antonie van Leeuwenhoek J. Microbiol. Serol. 61, pp. 135-142.

Schwaner, I. and Seifert, Roland and Schultz, Günter (1992) The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins. Eicosanoids 5 Suppl, S10-512.

1991

Kees, Frieder K. and Lukassek, U. and Naber, K. G. and Grobecker, H. (1991) Comparative investigations on the bioavailability of cefuroxime axetil. Arzneimittel-Forschung 41 (8), pp. 843-846.

Seifert, Roland and Schultz, Günter (1991) The superoxide- forming NADPH oxidase of phagocytes: an enzyme system regulated by multiple mechanisms. Reviews of physiology, biochemistry, and pharmacology, 117. Springer, Berlin. ISBN 3-540-53663-9, 0-387-53663-9.

1990

Kees, Frieder K. and Dehner, R. and Dittrich, W. and Raasch, W. and Grobecker, H. J. (1990) Untersuchungen zur Bioverfügbarkeit von Doxycy [The bioavailability of doxycycline]. Arzneimittel-Forschung 40 (9), pp. 1039-1043.

Seifert, Roland and Schultz, Günter and Richter-Freund, M. and Metzger, J. and Wiesmüller, K. H. and Jung, G. and Bessler, W. G. and Hauschildt, S. (1990) Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides. The Biochemical journal 267 (3), pp. 795-802.

Jungblut, P. R. and Seifert, Roland (1990) Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells. Journal of biochemical and biophysical methods 21 (1), pp. 47-58.

Burde, Rahel and Buschauer, Armin and Seifert, Roland (1990) Characterization of histamine H_2-receptors in human neutrophils with a series of guanidine analogues of impromidine: Are cell type-specific H_2-receptors involved in the regulation of NADPH oxidase? Naunyn-Schmiedeberg's Archives of Pharmacology 341, pp. 455-461.

Kees, Frieder K. and Raasch, W. and Steger, M. and Grobecker, H. (1990) High-performance liquid chromatographic assay for cefotiam and d3-cefotiam in human serum. Journal of Chromatography B 525 (2), pp. 484-489.

Wenzel-Seifert, Katharina and Seifert, Roland (1990) Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells. Immunobiology 181 (4-5), pp. 298-316.

Kees, Frieder K. and Naber, K. G. (1990) Pharmakokinetik von Cefixim bei Probanden und ein Literaturvergleich mit neuen Ester Prodrug Cephalosporinen [Pharmacokinetics of cefixime in volunteers and a literature comparison with the new ester prodrug cephalosporins]. Infection 18 Suppl 3, S150-S154.

Kees, Frieder K. and Naber, K. G. and Sigl, G. and Ungethüm, W. and Grobecker, H. J. (1990) Relative bioavailability of three cefixime formulations. Arzneimittel-Forschung 40 (3), pp. 293-297.

Korting, H. C. and Schäfer-Korting, M. and Kees, Frieder K. and Lukacs, A. and Grobecker, H. (1990) Skin tissue fluid levels of cefotiam in healthy man following oral cefotiam hexetil. European journal of clinical pharmacology 39 (1), pp. 33-36.

1989

Seifert, Roland and Burde, R. and Schultz, Günter (1989) Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides. The Biochemical journal 259 (3), pp. 813-819.

Engel, K. J. and Schmidt, W. and Sonntag, H. G. and Kees, Frieder K. (1989) Comparative clinical and pharmacokinetic aspects of cefotetan versus cefoxitin plus metronidazole in vaginal hysterectomy. Journal of chemotherapy 1 (4 Supl), pp. 1053-1056.

Seifert, Roland and Jungblut, P. and Schultz, Günter (1989) Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells. Biochemical and biophysical research communications 161 (3), pp. 1109-1117.

Naber, K. G. and Sörgel, F. and Kees, Frieder K. and Schumacher, H. and Sigl, G. and Zürcher, J. and Berger, S. (1989) Enoxacin-Konzentrationen in der Samenflüssigkeit, im Prostatasekret und im Prostataadenomgewebe nach oraler Gabe oder intravenöser Infusion [Enoxacin concentration in seminal fluid, in prostate secretions and in prostatic adenoma tissue following oral administration or intravenous infusion]. Infection 17 Suppl 1, S30-S66.

Schmidt, H. H. and Seifert, Roland and Böhme, E. (1989) Formation and release of nitric oxide from human neutrophils and HL-60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4. FEBS letters 244 (2), pp. 357-360.

Rudolph, U. and Koesling, D. and Hinsch, K. D. and Seifert, Roland and Bigalke, M. and Schultz, Günter and Rosenthal, W. (1989) G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils. Molecular and cellular endocrinology 63 (1-2), pp. 143-153.

Burde, Rahel and Seifert, Roland and Buschauer, Armin and Schultz, Günther (1989) Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H_2-receptors. Naunyn-Schmiedeberg's archives of pharmacology 340, pp. 671-678.

Seifert, Roland and Schultz, Günter (1989) Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides. Trends in pharmacological sciences 10 (9), pp. 365-369.

Seifert, Roland and Burde, R. and Schultz, Günter (1989) Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells. Naunyn-Schmiedeberg's archives of pharmacology 340 (1), pp. 101-106.

Kees, Frieder K. and Naber, K. G. and Meyer, G. P. and Grobecker, H. (1989) Pharmacokinetics of ciprofloxacin in elderly patients. Arzneimittel-Forschung 39 (4), pp. 523-527.

Naber, K. G. and Sörgel, F. and Kees, Frieder K. and Jaehde, U. and Schumacher, H. (1989) Pharmacokinetics of ciprofloxacin in young (healthy volunteers) and elderly patients, and concentrations in prostatic fluid, seminal fluid, and prostatic adenoma tissue following intravenous administration. The American journal of medicine 87 (5supl1), S57-S59.

Seifert, Roland and Wenzel, Katharina and Eckstein, F. and Schultz, Günter (1989) Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins. European journal of biochemistry / FEBS 181 (1), pp. 277-285.

Kujath, P. and Düsel, W. and Bruch, H. P. and Kees, Frieder K. (1989) The pharmacokinetic properties of cefotetan and its relevance for prophylaxis in elective colorectal surgery. Journal of chemotherapy 1 (4 Supl), pp. 1002-1004.

1988

Seifert, Roland and Schächtele, C. and Rosenthal, W. and Schultz, Günter (1988) Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol. Biochemical and biophysical research communications 154 (1), pp. 20-26.

Engel, K. J. and Schmidt, W. and Sonntag, H. G. and Kees, Frieder K. (1988) Comparative clinical and pharmacokinetic aspects of cefotetan versus cefoxitin plus metronidazole in vaginal hysterectomy. Chemioterapia 7 (4), pp. 256-260.

Naber, K. G. and Sörgel, F. and Kees, Frieder K. and Schumacher, H. and Metz, R. and Grobecker, H. (1988) In-vitro activity of fleroxacin against isolates causing complicated urinary tract infections and concentrations in seminal and prostatic fluid and in prostatic adenoma tissue. The Journal of antimicrobial chemotherapy 22 Suppl D, pp. 199-207.

Kees, Frieder K. and Naber, K. G. and Schumacher, H. and Grobecker, H. (1988) Penetration of fleroxacin into prostatic secretion and prostatic adenoma tissue. Chemotherapy 34 (6), pp. 437-443.

Schächtele, C. and Seifert, Roland and Osswald, H. (1988) Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. Biochemical and biophysical research communications 151 (1), pp. 542-547.

Seifert, Roland and Schächtele, C. (1988) Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase. Biochemical and biophysical research communications 152 (2), pp. 585-592.

Kujath, P. and Düsel, W. and Bruch, H. P. and Kees, Frieder K. (1988) The pharmacokinetic properties of cefotetan and its relevance for prophylaxis in elective colorectal surgery. Chemioterapia 7 (4), pp. 229-232.

Seifert, Roland and Rosenthal, W. and Schultz, Günter and Wieland, T. and Gierschick, P. and Jakobs, K. H. (1988) The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides. European journal of biochemistry / FEBS 175 (1), pp. 51-55.

1987

Seifert, Roland and Schächtele, C. and Schultz, Günter (1987) Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol. Biochemical and biophysical research communications 149 (2), pp. 762-768.

Naber, K. and Kees, Frieder K. and Denk, K. and Bauernfeind, A. and Grobecker, H. (1987) Carumonam versus ceftazidime: in vitro activity, pharmacokinetics in elderly patients, safety and therapeutic efficacy in the treatment of complicated urinary tract infections. Chemioterapia 6 (2 Supl), pp. 517-518.

Seifert, Roland and Schultz, Günter (1987) Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is potentiated by stable guanine nucleotides. European journal of biochemistry / FEBS 162 (3), pp. 563-569.

Naber, K. G. and Adam, D. and Kees, Frieder K. (1987) In vitro activity and concentrations in serum, urine, prostatic secretion and adenoma tissue of ofloxacin in urological patients. Drugs 34 Suppl 1, S44-S50.

Seifert, Roland and Schultz, Günter (1987) Reversible activation of NADPH oxidase in membranes of HL-60 human leukemic cells. Biochemical and biophysical research communications 146 (3), pp. 1296-1302.

Kees, Frieder K. and Dominiak, P. and Grobecker, H. (1987) Untersuchungen zur Bioverfügbarkeit von Heptaminol bei Probanden [Bioavailability of heptaminol in healthy subjects]. Arzneimittel-Forschung 37 (10), pp. 1182-1185.

Grobecker, H. and Kees, Frieder K. and Linden, M. and Schrader, E. and Welte, S. (1987) Untersuchungen zur Bioverfügbarkeit von Midodrin und 2,5- Dimethoxyphenyl-ß-aminoethanol-hydrochlorid [The bioavailability of midodrin and alpha-2,5-dimethoxyphenyl-beta-aminoethanol hydrochloride]. Arzneimittel-Forschung 37 (4), pp. 447-450.

1986

Dominiak, P. and Kees, Frieder K. and Grobecker, H. (1986) Circulating and tissue catecholamines in rats with chronic neurogenic hypertension. Basic research in cardiology 81 (1), pp. 20-28.

Seifert, Roland and Rosenthal, W. and Schultz, Günter (1986) Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils. FEBS letters 205 (1), pp. 161-165.

Martinez, C. and Dominiak, P. and Kees, Frieder K. and Grobecker, H. (1986) Inhibition of monoamine oxidase by viloxazine in rats. Arzneimittel-Forschung 36 (5), pp. 800-803.

Seifert, Roland (1986) Nikotinamidmethylierung in normalen Geweben und Tumorzellen von Ratte und Maus. PhD, Berlin, Freie Universität.

Naber, K. G. and Dette, G. A. and Kees, Frieder K. and Knothe, H. and Grobecker, H. (1986) Pharmacokinetics, in-vitro activity, therapeutic efficacy and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections. The Journal of antimicrobial chemotherapy 17 (4), pp. 517-527.

1985

Grobecker, H. and Gessler, I. and Delius, W. and Dominiak, P. and Kees, Frieder K. (1985) Effect of ketanserin on hemodynamics, plasma-catecholamine concentrations, and serotonin uptake by platelets in volunteers and patients with congestive heart failure. Journal of cardiovascular pharmacology 7, Suppl 7, S102-S104.

Kees, Frieder K. and Naber, K. G. and Bartoschik-Wich, B. and Stockmann, P. and Meyer, G. P. and Grobecker, H. (1985) High-performance liquid chromatography analysis of mezlocillin, piperacillin, their degradation products, and of ioxitalamic acid in plasma and urine of healthy volunteers. Arzneimittel-Forschung 35 (7), pp. 1099-1104.

Dominiak, P. and Kees, Frieder K. and Grobecker, H. (1985) Sympathoadrenal dysfunction in rats with chronic neurogenic hypertension. European journal of pharmacology 107 (2), pp. 263-266.

1984

Dominiak, P. and Kees, Frieder K. and Grobecker, H. (1984) Changes in peripheral and central catecholaminergic and serotoninergic neurons of rats after acute and subacute administration of nicotine. Klinische Wochenschrift. Supplementum 62 Suppl 2, pp. 76-80.

Kees, Frieder K. and Grobecker, H. and Naber, K. G. (1984) High-performance liquid chromatographic analysis of cefotetan epimers in human plasma and urine. Journal of Chromatography B 305 (2), pp. 363-371.

1983

Schleicher, E. D. and Kees, Frieder K. and Wieland, O. H. (1983) Analysis of total urinary catecholamines by liquid chromatography: methodology, routine experience and clinical interpretations of results. Clinica chimica acta 129 (3), pp. 295-302.

Kees, Frieder K. and Strehl, E. and Dominiak, P. and Grobecker, H. and Seeger, K. and Seidel, G. and Neuhaus, B. and Safrany, L. (1983) Cefotaxime and desacetyl cefotaxime in human bile. Infection 11 (2), pp. 118-120.

Naber, K. G. and Kees, Frieder K. and Grobecker, H. (1983) Ceftazidime: pharmacokinetics in young volunteers versus elderly patients and therapeutic efficacy with complicated urinary tract infections. The Journal of antimicrobial chemotherapy 12 Suppl A, pp. 41-45.

1981

Kees, Frieder K. and Strehl, E. and Seeger, K. and Seidel, G. and Dominiak, P. and Grobecker, H. (1981) Comparative determination of cefotaxime and desacetyl cefotaxime in serum and bile by bioassay and high-performance liquid chromatography. Arzneimittel-Forschung 31 (2), pp. 362-365.

1976

Kees, Frieder K. (1976) Thiaziridindioxide, Thiadiaziridindioxide und ein Beitrag zur Staudinger-Pfenninger-Reaktion. PhD, Univ. Würzburg.

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