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Anzahl der Einträge in dieser Kategorie: 211.

2016

Schlossmann, Jens, Wetzl, Veronika, Schinner, Elisabeth, Kees, Frieder K., Hofmann, Franz und Faerber, Lothar (2016) Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin. Frontiers in Pharmacology 7 (195), S. 1-27.

Kratzer, Alexander Ludwig (2016) Entwicklung und Erprobung von HPLC-basierten Methoden für das Therapeutische Drug-Monitoring von Betalaktam-Antibiotika, Linezolid und Tigecyclin – Bestimmung von freien und totalen Konzentrationen im Plasma von Intensivpatienten. Dissertation, Universität Regensburg.

Limmer, Franziska (2016) Funktionelle Analyse der cGMP-abhängigen Proteinkinase I in der Niere, insbesondere im dicken aufsteigenden Ast der Henle-Schleife. Dissertation, Universität Regensburg.

Stangl, Hubert Werner (2016) Arthritis and cholinergic transition of sympathetic nerve fibers. Dissertation, Universität Regensburg.

Vögeler, Jessica (2016) Pharmakotherapie und Humanpharmakologische Untersuchungen bei Patienten mit DME (Diabetisches Makulaödem) und PDR (Proliferative Diabetische Retinopathie) anhand klinischer Parameter und inflammatorischer Biomarker. Dissertation, Universität Regensburg.

2015

Wolfertstetter, Stefanie (2015) Funktion von cCMP und cCMP-spezifischen Signalwegen. Dissertation, Universität Regensburg.

Wolferstetter, Stefanie, Reinders, Jörg, Schwede, Frank, Ruth, Peter, Schinner, Elisabeth und Schlossmann, Jens (2015) Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues. PLoS ONE 10 (5), e0126057.

Huber, Stefan, Huettner, Johannes Philip, Kristina, Hacker, Bernhardt, Günther, König, Jörg und Buschauer, Armin (2015) Esters of bendamustine are by far more potent cytotoxic agents than the parent compound against human sarcoma and carcinoma cells. PLoS One 10 (7), PLoSe0133743.

Strasser, Andrea, Wittmann, Hans-Joachim, Schneider, Erich H. und Seifert, Roland (2015) Modulation of GPCRs by monovalent cations and anions. Naunyn-Schmiedeberg's Archives of Pharmacology 388, S. 363-380. Volltext nicht vorhanden.

2014

Haunschild, Gundula (2014) Nachweis und molekulare Charakterisierung EpCAM-positiver Zellen im Knochenmark von Mammakarzinom-Patientinnen. Dissertation, Universität Regensburg.

Schramm, Andrea (2014) Analyse renaler Funktionen der cGMP-abhängigen Proteinkinase II. Dissertation, Universität Regensburg.

2013

Kees, Martin Georg, Schaeftlein, André, Haeberle, Helene Anna, Kees, Frieder K., Kloft, Charlotte und Heininger, Alexandra (2013) Population pharmacokinetics and pharmacodynamic evaluation of intravenous and enteral moxifloxacin in surgical intensive care unit patients. The Journal of antimicrobial chemotherapy. Volltext nicht vorhanden.

Chen, W., Oberwinkler, H., Werner, F., Gaßner, B., Nakagawa, H,, Feil, R., Hofmann, F., Schlossmann, Jens, Dietrich, A., Gudermann, T., Nishida, M., Del Galdo, S., Wieland, T. und Kuhn, M. (2013) ANP-mediated inhibition of microcirculatory endothelial Ca 2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels. Arteriosclerosis, Thrombosis, and Vascular Biology 33 (9), S. 2121-2129. (Im Druck) Volltext nicht vorhanden.

Dietrich, P., Moleda, Lukas, Kees, Frieder K., Müller, M., Straub, R. H., Hellerbrand, C. und Wiest, R. (2013) Dysbalance in sympathetic neurotransmitter release and action in cirrhotic rats: impact of exogenous neuropeptide Y. Journal of hepatology 58 (2), S. 254-261. Volltext nicht vorhanden.

Schlossmann, Jens (2013) Editorial of the Special issue: signalling molecules and Signal transduction in cells. Int. J. Mol. Sci. 14, 1-x, doi:103390/ijms140x000x 14 (6), S. 11438-11443. Volltext nicht vorhanden.

Salb, Katharina und Schlossmann, Jens (2013) Methods for identification of cGKI substrates. In: Nicht ausgewählt Methods in Molecular Biology, 1020. Methods in Molecular Biology, S. 147-162. Volltext nicht vorhanden.

Schinner, E., Schramm, A., Kees, F., Hofmann, F. und Schlossmann, Jens (2013) Suppression of kidney fibrosis by cGMP-dependent protein Kinase Ia. Kidney International. (Im Druck) Volltext nicht vorhanden.

Wolfertstetter, Stefanie, Huettner, Johannes Philip und Schlossmann, Jens (2013) cGMP-dependent Protein Kinase Inhibitors in Health and Disease. Pharmaceuticals 6, S. 269-286.

2012

Hieke, Bernhard (2012) Bedeutung von IRAG für die Calciumregulation im glatten Muskel. Dissertation, Universität Regensburg.

Salb, Katharina (2012) Funktion von IRAG für cGMP-Kinase-I-Komplexe sowie für die InsP3R-I-Phosphorylierung. Dissertation, Universität Regensburg.

Peter, Katrin (2012) Einfluss der Tumormetaboliten 5'-Deoxy-5'-Methylthioadenosin und Milchsäure auf humane Monozyten. Dissertation, Universität Regensburg.

Deml, Karl-Friedrich (2012) Interaktionen von Histamin H1-Rezeptoragonisten und
–antagonisten mit dem humanen Histamin H4-Rezeptor.
Dissertation, Universität Regensburg.

Schlossmann, Jens und Schinner, E. (2012) cGMP becomes a drug target. Naunyn Schmiedeberg´s Archives of Pharmacology 385 (3), S. 243-252.

Doser, Kristina (2012) Untersuchungen zur B-Zell-Rekonstitution nach allogener Stammzelltransplantation. Dissertation, Universität Regensburg.

Rupprecht, Korbinian (2012) Einfluss von Pantoprazol auf die Bioverfügbarkeit von Mycophenolsäure aus CellCept® bzw. myfortic®: Pharmakokinetische Untersuchungen in vitro und an Probanden. Dissertation, Universität Regensburg.

Salb, Katharina, Schinner, Elisabeth und Schlossmann, Jens (2012) Identification of cGMP-Kinase complexes by affinity chromatography. In: INTECH Chapter in Affinity Chromatography. , S. 255-272. ISBN 978-953-51-0325-7. Volltext nicht vorhanden.

Taha, Hesham, Dove, Stefan, Geduhn, Jens, König, Burkhard, Shen, Yuequan, Tang, Wei-Jen und Seifert, Roland (2012) Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 monoand bis-(M)ANT-substituted nucleoside 5′-triphosphates. Naunyn-Schmiedeberg's Archives of Pharmacology (385), S. 57-68. Volltext nicht vorhanden.

Kees, Martin G., Steinke, T., Moritz, S., Rupprecht, K., Paulus, E. M., Kees, Frieder K., Bucher, M. und Faerber, L. (2012) Omeprazole impairs the absorption of mycophenolate mofetil but not of enteric-coated mycophenolate sodium in healthy volunteers. Journal of clinical pharmacology 52 (8), S. 1265-1272. Volltext nicht vorhanden.

Justinger, Christoph, Schilling, Martin K., Kees, Martin G., Kauffels, Anne, Hirschmann, Katrin, Kopp, Berit, Kees, Frieder K. und Kollmar, Otto (2012) Penetration of moxifloxacin into liver tissue. International journal of antimicrobial agents 39 (6), S. 505-509. Volltext nicht vorhanden.

Luo, C., Gangadharan, V., Bali, K.K., Xie, R.G., Agarwal, N., Kurejova, M., Tappe-Theodor, A., Tegeder, I., Feil, S., Lewin, G., Polgar, E., Todd, A.J., Schlossmann, Jens, Hofmann, F., Liu, D.L., Hu, S.J., Feil, R., Kuner, T. und Kuner, R. (2012) Presynaptically localized cyclic GMP-dependent Protein Kinase I is a key determinant of spinal potentiation and pain hypersensitivity. PLoS Biology 10 (3), 1e1001283.

Jaumann, M., Dettling, J., Gubelt, M., Zimmermann, U., Gerling, A., Paquet-Durand , F., Feil, S., Wolpert, S., Franz, C., Varakina, K., Xiong, H., Brandt, N., Kuhn, S., Geisler, H.-S., Rohbock, K., Ruth, P., Schlossmann, Jens, Hütter, J., Sandner, P., Feil, R., Engel, J., Knipper, M. und Rüttiger, L. (2012) cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and heraring function. Nature Medicine 18, S. 252-259. Volltext nicht vorhanden.

2011

Hübner, Melanie, Dixit, A., Mou, T.-C., Lushington, Gerald H., Pinto, Cibele S., Gille, A., Geduhn, Jens, König, Burkhard, Sprang, S. R. und Seifert, Roland (2011) Structural Basis for the High-Affinity Inhibition of Mammalian Membranous Adenylyl Cyclase by 2`,3`-O-(N-Methylanthraniloyl)-Inosine 5`-Triphosphate. Molecular Pharmacology 80 (1), S. 87-96. Volltext nicht vorhanden.

Schinner, Elisabeth (2011) Funktionelle Studie der NO/cGMP Signalkaskade in Niere und Thrombozyten. Dissertation, Universität Regensburg.

Erdorf, Miriam und Seifert, Roland (2011) Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (4), S. 357-372. Volltext nicht vorhanden.

Kellermann, K., Dertinger, N., Blobner, M., Kees, Frieder, Kochs, E. F. und Jungwirt, B. (2011) Perioperative moxifloxacin treatment in rats subjected to deep hypothermic circulatory arrest: reduction in cerebral inflammation but without improvement in cognitive performance. Journal of Thoracic and Cardiovascular Surgery 141 (3), S. 796-802. Volltext nicht vorhanden.

Schnell, David, Brunskole, Irena, Ladova, Katerina, Schneider, Erich H., Igel, Patrick, Dove, Stefan, Buschauer, Armin und Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), S. 457-470. Volltext nicht vorhanden.

Geduhn, Jens, Dove, Stefan, Shen, Yuequan, Tang, Wei-Jen, König, Burkhard und Seifert, Roland (2011) Bis-Halogen-Anthraniloyl-Substituted Nucleoside 5'-triphosphates as Potent and Selective Inhibitors of Bordetella pertussis CyaA. The Journal of pharmacology and experimental therapeutics 336 (1), S. 104-115. Volltext nicht vorhanden.

Schinner, Elisabeth, Salb, Katharina und Schlossmann, Jens (2011) Signaling via IRAG is essential for NO/cGMP-dependent inhibition of platelet activitation. Platelets. Volltext nicht vorhanden.

Salb, Katharina, Schinner, Elisabeth und Schlossmann, Jens (2011) Function of IRAG and the phosphorylation of the InsP3R-I for the NO/cGMP-dependent inhibition of platelet aggregation. BMC Pharmacology (11), P58.

Schlossmann, Jens und Desch, M. (2011) IRAG and Novel PKG Targeting in the cardiovascular system. American Journal of Physiology- Heart und Circulatory Physiology 301, H672-682. Volltext nicht vorhanden.

Ertl, C., Lukowski, R., Sigl, K, Schlossmann, Jens, Hofmann, F. und Wegener, Jörg W. (2011) Kinetics of relaxation by cGMP/cGKI signaling in fundus smooth muscle. Eur J Pharmacol 670 (1), S. 266-271. Volltext nicht vorhanden.

Kees, Martin G., Weber, Susanne, Kees, Frieder K. und Horbach, Thomas (2011) Pharmacokinetics of moxifloxacin in plasma and tissue of morbidly obese patients. The Journal of antimicrobial chemotherapy 66 (10), S. 2330-2335. Volltext nicht vorhanden.

Pinto, Cibele S., Lushington, Gerald H., Richter, M., Gille, A., Geduhn, Jens, König, Burkhard, Mou, T.-C., Sprang, S. R. und Seifert, Roland (2011) Structure–activity relationships for the interactions of 2`- and 3`-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases. Biochemical Pharmacology 82 (4), S. 358-370. Volltext nicht vorhanden.

Werder, A., Mayr, M., Schneider, G., Oesterle, D., Fritsch, R. M., Seidler, B., Schlossmann, Jens, Hofmann, F., Schemann, M., Allescher, H. D., Schmid, R.M. und Saur, D. (2011) Truncated IRAG variants modulate cGMP-mediated inhibition of human colonic smooth muscle cell contraction. American Journal of Physiology - Cell Physiology : Am J Physiol Cell Physiol 301 (6), C1445-1457. Volltext nicht vorhanden.

2010

Kees, MG, Hilpert, JW, Gnewuch, C, Kees, F. und Voegeler, S. (2010) Clearance of vancomycin during continuous infusion in intensive care unit patients: correlation with measured and estimated creatinine clearance and serum cystatin C. International Journal of Antimicrobial Agents 36 (6), S. 545-548. Volltext nicht vorhanden.

Appl, Heidrun (2010) Molecular analysis of the interaction of the four histamine receptor subtypes with antidepressant and antipsychotic drugs. Dissertation, Universität Regensburg.

Schnell, David, Strasser, Andrea und Seifert, Roland (2010) Comparison of the pharmacological properties of human and rat histamine H(3)-receptors. Biochemical Pharmacology 80 (9), S. 1437-1449. Volltext nicht vorhanden.

Erdorf, Miriam (2010) Regulation of mammalian membranous adenylyl cyclases by diterpenes and MANT-nucleotides. Dissertation, Universität Regensburg.

Desch, Matthias (2010) Funktionelle Charakterisierung des cGMP-abhängigen Proteinkinase-Substrates IRAG und des potentiellen "second messenger" zyklisches Cytidin-3',5'-monophosphat im glatten Muskel. Dissertation, Universität Regensburg.

Hübner, Melanie (2010) Crystal structure of the catalytic domains of membranous adenylyl cyclase with MANT-ITP and electrophysiological analysis of MANT nucleotides in cardiomyocytes. Dissertation, Universität Regensburg.

Mathar, I., Vennekens, R., Meissner, M., Kees, Frieder K., Van der Mieren , G. und Camacho Londono, J. (2010) Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. The Journal of Clinical Investigation 120 (9), S. 3267-3279. Volltext nicht vorhanden.

Desch, Matthias, Schinner, Elisabeth, Kees, Frieder K., Hofmann, F., Seifert, Roland und Schlossmann, Jens (2010) Cyclic cytidine 3´,5´-monophosphate (cCMP) signals via cGMP kinase I. FEBS Letters 584 (18), S. 3979-3984. Volltext nicht vorhanden.

Schneider, E. H., Strasser, Andrea, Thurmond, R. L. und Seifert, Roland (2010) Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands. Journal of Pharmacology and Experimental Therapeutics 334 (2), S. 513-521. Volltext nicht vorhanden.

Spangler, Corinna (2010) Molecular and cellular analysis of the "adenylyl cyclase" exotoxins from Bacillus anthracis and Bordetella pertussis. Dissertation, Universität Regensburg.

Desch, Matthias, Sigl, K., Hieke, Bernhard, Salb, Katharina, Kees, F. und Bernhard, D. (2010) IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation. Cardiovascular Research 86 (3), S. 496-505. Volltext nicht vorhanden.

Weitl, Nina (2010) Interaktionen des humanen β1- und β2- Adrenorezeptors mit Isoproterenol, Epinephrin, Norepinephrin und Dopamin. Dissertation, Universität Regensburg.

Schnell, David und Seifert, Roland (2010) Modulation of Histamine H(3) receptor function by monovalent ions. Neuroscience Letters 472 (2), S. 114-118. Volltext nicht vorhanden.

Schnell, David, Burleigh, Katrina, Seifert, Roland und Trick, Jonathan (2010) No evidence for functional selectivity of proxyfan at the human histamine H3 receptor coupled to defined Gi/Go protein heterotrimers. Journal of Pharmacology and Experimental Therapeutics . JPET 332 (3), S. 996-1005. Volltext nicht vorhanden.

Schnell, David (2010) Molecular analysis of the histamine H3-receptor. Dissertation, Universität Regensburg.

Schilling, Elmar (2010) Analysis of tissue-specific & allele-specific DNA methylation. Dissertation, Universität Regensburg.

Mohammed, Hesham Hamada Taha (2010) Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin. Dissertation, Universität Regensburg.

Göttle, Martin, Dove, Stefan, Kees, Frieder K., Schlossmann, Jens, Geduhn, Jens, König, Burkhard, Shen , Y., Tang, W. J., Kaever, V. und Seifert, Roland (2010) Citidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA. Biochemistry 49, S. 5494-5503. Volltext nicht vorhanden.

Desch, M., Sigl, K., Hieke, B., Salb, Katharina, Kees, Frieder, Bernhard, D., Jochim , A., Spiessberger, B., Höcherl, K., Feil, R., Lukowski, R., Wegener, Jörg W., Hofmann, F. und Schlossmann, Jens (2010) IRAG determines NO- and ANP-mediated smooth muscle relaxation. Cardiovascular Research 86 (3), S. 496-505. Volltext nicht vorhanden.

Schneider, Erich H., Schnell, David, Strasser, Andrea, Dove, Stefan und Seifert, Roland (2010) Impact of the DRY Motif and the Missing "Ionic Lock" on Constitutive Activity and G-Protein Coupling of the Human Histamine H-4 Receptor. Journal of Pharmacology and Experimental Therapeutics 333 (2), S. 382-392. Volltext nicht vorhanden.

Schneider, Erich, Schnell, David, Strasser, Andrea, Dove, Stefan und Seifert, Roland (2010) Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor. J Pharmacol Exp Ther : The journal of pharmacology and experimental therapeutics 333 (2), S. 382-392. Volltext nicht vorhanden.

2009

Jouma, Louay (2009) Functional analysis of the mouse histamine H4 receptor in myeloid cells. Dissertation, Universität Regensburg.

Igel, Patrick, Geyer, Roland, Straßer, Andrea, Dove, Stefan, Seifert, Roland und Buschauer, Armin (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H(4) receptor agonists. Journal of Medicinal Chemistry 52 (20), S. 6297-6313. Volltext nicht vorhanden.

Ratzinger, Sabine (2009) Studies on the molecular interactions of collagen type XVI.
Part I: The role of collagen XVI in pathological disorders
Part II: Extablishment of a retroviral mediated gene silencing model.
Dissertation, Universität Regensburg.

Göttle, Martin (2009) Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins. Dissertation, Universität Regensburg.

Igel, Patrick, Schneider, Erich, Schnell, David, Elz, Sigurd, Seifert, Roland und Buschauer, Armin (2009) N(G)-Acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent. Journal of Medicinal Chemistry 52 (8), S. 2623-2627. Volltext nicht vorhanden.

Kraus, Anja, Ghorai, Prasanta, Birnkammer, Tobias, Schnell, David, Elz, Sigurd, Seifert, Roland, Dove, Stefan, Bernhardt, Günther und Buschauer, Armin (2009) N(G)-Acylated aminothiazolylpropylguanidines as potent and selective histamine H2 receptor agonists. ChemMedChem 4 (2), S. 232-240. Volltext nicht vorhanden.

Igel, Patrick, Schnell, David, Bernhardt, Günther, Seifert, Roland und Buschauer, Armin (2009) Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand. ChemMedChem 4 (2), S. 225-231. Volltext nicht vorhanden.

Frei, E., Huster, M., Smital, P., Schlossmann, Jens, Hofmann, F. und Wegener, Jörg W. (2009) Calcium-dependent and Calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle. American Journal of Physiology 297, G834-839. Volltext nicht vorhanden.

Seifert, Roland und Dove, Stefan (2009) Functional Selectivity of GPCR Ligand Stereoisomers: New Pharmacological Opportunities. Mol. Pharmacol. 75 (1), S. 13-18. Volltext nicht vorhanden.

Deml, Karl-Friedrich, Beermann , S, Neumann, Detlef, Strasser, Andrea und Seifert, Roland (2009) Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor. Mol Pharmacol : Molecular pharmacology 76 (5), S. 1019-1030. Volltext nicht vorhanden.

Taha, H. M., Schmidt, J., Göttle, M., Suryanarayana, S., Shen, Y., Tang, W.-J., Gille, A., Geduhn, Jens, König, Burkhard, Dove, Stefan und Seifert, Roland (2009) Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides. Mol. Pharmacol. 75 (3), S. 693-703. Volltext nicht vorhanden.

Egger, Michael, Maity, Prantik, Hübner, Melanie, Seifert, Roland und König, Burkhard (2009) Synthesis and pharmacological properties of new tetracyclic forskolin analogues. European Journal of Organic Chemistry 2009 (21), S. 3613-3618. Volltext nicht vorhanden.

Schlossmann, Jens und Desch, M. (2009) cGK substrates. Handbook of Experimental Pharmacology 191, S. 163-193. Volltext nicht vorhanden.

2008

Ghorai, Prasanta, Kraus, Anja, Keller, Max, Götte, Carsten, Igel, Patrick, Schneider, Erich, Schnell, David, Bernhardt, Günther, Dove, Stefan, Zabel, Manfred, Elz, Sigurd, Seifert, Roland und Buschauer, Armin (2008) Acylguanidines as bioisosteres of guanidines: N(G)-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry 51 (22), S. 7193-7204. Volltext nicht vorhanden.

Dove, Stefan, Seifert, Roland, Elz, Sigurd und Buschauer, Armin (2008) Frontiers in medicinal chemistry in Regensburg. ChemMedChem 3 (8), S. 1181-1184. Volltext nicht vorhanden.

Schlossmann, Jens und Hofmann, F. (2008) Receptor mediated mechanisms. In: Greim, H. und Snyder, R., (eds.) Toxicology and risk assessment : a comprehensive introduction. Wiley, Chicester. ISBN 978-0-470-86893-5. Volltext nicht vorhanden.

Schmidtko, A., Gao , W., König, P., Heine, S., Motterlini, R., Ruth, P., Schlossmann, Jens, Koesling, D., Niederberger, E., Tegeder, I., Friebe, A. und Geisslinger, G. (2008) cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. Journal of Neuroscience 28, S. 8568-8576. Volltext nicht vorhanden.

2007

Göttle, Martin, Dove, Stefan, Steindel, Phillip, Shen, Yuequan, Tang, Wei-Jen, Geduhn, Jens, König, Burkhard und Seifert, Roland (2007) Molecular Analysis of the Interaction of Bordetella pertussis Adenylyl Cyclase with Fluorescent Nucleotides. Molecular Pharmacology 72 (3), S. 526-535.

Lorenz, Veronika, Pinto, Cibele S. und Seifert, Roland (2007) Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency. Neuroscience Letters 420 (1), S. 6-11.

Wang, Jenna L., Guo, Jian-Xin, Zhang, Qi-Yuan, Wu, Jay J.-Q., Seifert, Roland und Lushington, Gerald H. (2007) A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified
and unmodified nucleotide inhibitors.
Bioorganic & Medicinal Chemistry 15 (8), S. 2993-3002.

Preuss, Hendrik, Ghorai, Prasanta, Kraus, Anja, Dove, Stefan, Buschauer, Armin und Seifert, Roland (2007) Constitutive Activity and Ligand Selectivity of Human,
Guinea Pig, Rat, and Canine Histamine H₂ Receptors.
Journal of Pharmacology and Experimental Therapeutics 321 (3), S. 983-995.

Preuss, Hendrik, Ghorai, Prasanta, Kraus, Anja, Dove, Stefan, Buschauer, Armin und Seifert, Roland (2007) Mutations of Cys-17 and Ala-271 in the Human Histamine H₂
Receptor Determine the Species Selectivity of Guanidine-Type Agonists and Increase Constitutive Activity.
Journal of Pharmacology and Experimental Therapeutics 321 (3), S. 975-982.

Xie, Sheng-Xue, Schalkhausser, Fabian, Ye, Qi-Zhuang, Seifert, Roland und Buschauer, Armin (2007) Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors. Archiv der Pharmazie 340 (1), S. 9-16.

Rottlaender, Dennis, Matthes, Jan, Vatner, Stephen F., Seifert, Roland und Herzig, Stefan (2007) Functional Adenylyl Cyclase Inhibition in Murine
Cardiomyocytes by 2'(3')-O-(N-Methylanthraniloyl)-Guanosine
5'-[γ-Thio]triphosphate.
Journal of Pharmacology and Experimental Therapeutics 321 (2), S. 608-615.

Antl, M., von Brühl, M. L., Eigslperger, C., Werner, M., Konrad, I., Köcher, T., Wilm, M., Hofmann, F., Massberg, S. und Schlossmann, Jens (2007) IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood 109, S. 552-559. Volltext nicht vorhanden.

Kees, F., Bucher, M., Schweda, F., Gschaidmeier, H., Faerber, L. und Seifert, R. (2007) Neoimmun versus Neoral: a bioequivalence study in healthy volunteers and influence of a fat-rich meal on the bioavailability of Neoimmun. Naunyn-Schmiedeberg's Archives of Pharmacology 375 (6), S. 393-399.

Preuss, Hendrik, Ghorai, Prasanta, Kraus, Anja, Dove, Stefan, Buschauer, Armin und Seifert, Roland (2007) Point Mutations in the Second Extracellular Loop of the Histamine H2 Receptor do not affect the Species-Selective Activity of Guanidine-Type Agonists. Naunyn Schmiedebergs Arch. Pharmacol. 376 (4), S. 253-264. Zugang zum Volltext eingeschränkt.

Sausbier, M., Zhou, X.B., Beier, C., Sausbier, U., Wolpers , D., Maget, S., Martin, C., Dietrich, A., Ressmeyer, A.R., Schlossmann, Jens, Hofmann, F., Neuhuber, W., Gudermann, T., Uhlig, S., Korth, M. und Ruth, P. (2007) Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+channel. FASEB Journal 21, S. 812-822. Volltext nicht vorhanden.

Weber, S., Bernhard, D., Lukowski, R., Weinmeister, P., Wörner, R., Wegener, J. W., Valtcheva, N., Feils, S., Schlossmann, Jens, Hofmann, F. und Feil, R. (2007) Rescue of cGMP Kinase I knockout mice by smooth muscle specific expression of either isozyme. Circulation Research 101, S. 1096-1103. Volltext nicht vorhanden.

2006

Kees, Frieder, Bucher, Michael, Schweda, Frank, Gschaidmeier, Harald, Burhenne, Juergen, Mikus, Gerd und Faerber, Lothar (2006) Comparative bioavailability of the microemulsion formulation of cyclosporine (Neoral) with a generic dispersion formulation (Cicloral) in young healthy male volunteers. Therapeutic drug monitoring 28 (3), S. 312-320. Zugang zum Volltext eingeschränkt.

Xie, Sheng-Xue, Kraus, Anja, Ghorai, Prasanta, Ye, Qi-Zhuang, Elz, Sigurd, Buschauer, Armin und Seifert, Roland (2006) N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-
yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2- Receptors.
Journal of Pharmacology and Experimental Therapeutics 317 (3), S. 1262-1268. Zugang zum Volltext eingeschränkt.

Xie, Sheng-Xue, Ghorai, Prasanta, Ye, Qi-Zhuang, Buschauer, Armin und Seifert, Roland (2006) Probing Ligand-Specific Histamine H1- and H2-Receptor
Conformations with NG-Acylated Imidazolylpropylguanidines.
The Journal of Pharmacology and Experimental Therapeutics 317 (1), S. 139-146. Zugang zum Volltext eingeschränkt.

Pinto, Cibele S. und Seifert, Roland (2006) Decreased GTP-stimulated adenylyl cyclase activity in
HPRT-deficient human and mouse fibroblast and rat
B103 neuroblastoma cell membranes.
Journal of Neurochemistry 96 (2), S. 454-459. Zugang zum Volltext eingeschränkt.

Hofmann, F., Feil, R., Kleppisch, T. und Schlossmann, Jens (2006) Function of cGMP-dependent Protein Kinase as revealed by gene deletion. Physiological Reviews 86, S. 1-23. Volltext nicht vorhanden.

2005

Feil, S., Zimmermann, P., Knorn, A., Brummer, S., Schlossmann, Jens, Hofmann, F. und Feil, R. (2005) Distribution of cGMP-dependent protein kinase type 1 and its isoforms in the mouse brain and retina. Neuroscience 135, S. 863-868. Volltext nicht vorhanden.

Schlossmann, Jens, Feil, R. und Hofmann, F. (2005) Insights into cGMP signaling derived from cGMP Kinase knockout mice. Frontiers in Bioscience 10, S. 1279-1289. Volltext nicht vorhanden.

Werner, C.G., Godrey, V., Arnold, R.R., Featherstone, G.L., Bender, D., Schlossmann, Jens, Schiemann, M., Hofmann, F. und Pryzwansky, K.B. (2005) Neutrophil dysfunction in guanosine 3',5'-cyclic monophosphate-dependent protein kinase I-deficient mice. Journal of Immunology 175, S. 1919-1929. Volltext nicht vorhanden.

Schlossmann, Jens und Hofmann, F. (2005) cGMP-dependent protein kinases in drug discovery. Drug Discovery Today 10, S. 627-634. Volltext nicht vorhanden.

2004

Geiselhöringer, A., Gaisa, M., Hofmann, F. und Schlossmann, Jens (2004) Distribution of IRAG and cGKI-isoforms in murine tissues. FEBS Letters 575, S. 19-22. Volltext nicht vorhanden.

Geiselhöringer, A., Werner, M., Sigl, K., Smital, P., Wörner, R., Acheo, L., Stieber, J., Weinmeister, P., Feil, R., Feil, S., Wegener, J., Hofmann, F. und Schlossmann, Jens (2004) IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP Kinase. EMBO Journal 23, S. 4222-4231. Volltext nicht vorhanden.

Fritsch, R.M., Saur, D., Kurjak, M., Oesterle, D., Schlossmann, Jens, Geiselhöringer, A., Hofmann, F. und Allescher, H. D. (2004) InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle. J. Biol. Chem. 279, S. 12551-12559. Volltext nicht vorhanden.

Dove, Stefan, Elz, Sigurd, Seifert, Roland und Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), S. 941-954. Volltext nicht vorhanden.

2003

Koller, A., Schlossmann, Jens, Ashman, K., Uttenweiler-Joseph, S., Ruth, P. l. und Hofmann, F. (2003) Association of phospholamban with a cGMP kinase signaling complex. Biochemical and Biophysical Research Communications : Biochem. Biophys. Res. Commun. 300, S. 155-160. Volltext nicht vorhanden.

Seifert, Roland, Wenzel-Seifert, Katharina, Bürckstümmer, Tilmann, Pertz, Heinz H., Schunack, Walter, Dove, Stefan, Buschauer, Armin und Elz, Sigurd (2003) Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,. Journal of Pharmacology and Experimental Therapeutics 305, S. 1104-1115. Volltext nicht vorhanden.

Schlossmann, Jens, Feil, R. und Hofmann, F. (2003) Signaling through NO and cGMP-dependent protein kinases. Annals of Medicine 35, S. 21-27. Volltext nicht vorhanden.

2002

Feil, R., Gappa, N., Rutz, M., Schlossmann, Jens, Rose, C.R., Konnerth, A., Brummer, S. und Hofmann, F. (2002) Functional Reconstitution of vascular smooth muscle cells with cGMP-dependent protein kinase I isoforms. Circulation Research : Circ. Res. 90, S. 1080-1086. Volltext nicht vorhanden.

2001

Kelley, Melissa T., Bürckstümmer, Tilmann, Wenzel-Seifert, Katharina, Dove, Stefan, Buschauer, Armin und Seifert, Roland (2001) Distinct interaction of human and guinea pig histamine H_2-Receptor with guanidine-type agonists,. Molecular Pharmacology 60 (6), S. 1210-1225. Volltext nicht vorhanden.

Ammendola, A., Geiselhöringer, A., Hofmann, F. und Schlossmann, Jens (2001) Molecular Determinants of the Interaction between the Inositol 1,4,5-Trisphosphate Receptor-associated cGMP Kinase Substrate (IRAG) and cGMP Kinase Iβ. J. Biol. Chem. 276, S. 24153-24159. Volltext nicht vorhanden.

Wenzel-Seifert, Katharina, Kelley, Melissa T., Buschauer, Armin und Seifert, Roland (2001) Similar apparent constitutive activity of human histamine H_2-receptor fused to long and short splice variants of Gsa,. Journal of Pharmacology and Experimental Therapeutics 299 (3), S. 1013-1020. Volltext nicht vorhanden.

2000

Schlossmann, Jens, Ammendola, A., Ashman, K., Zong, X, Huber, A., Neubauer, G., Wang, G. X., Allescher, H. D., Korth, M., Wilm, M., Hofmann, F. und Ruth, P. (2000) Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Nature 404, S. 197-201. Volltext nicht vorhanden.

Hofmann, F., Ammendola, A. und Schlossmann, Jens (2000) Rising behind NO: cGMP-dependent protein kinases. Journal of cell science : J. Cell Sci. 113, S. 1671-1676. Volltext nicht vorhanden.

1999

Gaburjakova, M., Schlossmann, Jens und Ondrias, K. (1999) Properties of a new calcium-permeable single channel from tracheal microsomes. Biochimica et Biophysica Acta : BBA. Biomembranes 1417, S. 25-31. Volltext nicht vorhanden.

1998

Zhou, X.B., Schlossmann, Jens, Hofmann, F., Ruth, P. und Korth, M. (1998) Regulation of stably expressed and native BK channels from human myometrium by cGMP- and cAMP-dependent protein kinase. Pflügers Archiv : European journal of physiology 436, S. 725-734. Volltext nicht vorhanden.

1996

Zhou , X. B., Ruth, P., Schlossmann, Jens, Hofmann, F. und Korth, M. (1996) Protein Phosphatase 2A Is Essential for the Activation of Ca2+-activated K+ Currents by cGMP-dependent Protein Kinase in Tracheal Smooth Muscle and Chinese Hamster Ovary Cells. Journal of Biological Chemistry : J. Biol Chem 271, S. 19760-19767. Volltext nicht vorhanden.

Schlossmann, Jens, Lill, R., Neupert, W. und Court, D. A. (1996) Tom71, a novel homologue of the mitochondrial preprotein receptor Tom70. The journal of biological chemistry : J. Biol. Chem. 271, S. 17890-17895. Volltext nicht vorhanden.

1995

Schlossmann, Jens und Neupert, W. (1995) Assembly of the preprotein receptor MOM72/MAS70 into the protein import complex of the outer membrane of mitochondria. J. Biol Chem 270, S. 27116-27121. Volltext nicht vorhanden.

Hagelüken, Astrid, Burde, Rahel, Nürnberg, Bern, Harhammer, R., Buschauer, Armin und Seifert, Roland (1995) Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism. Naunyn Schmiedeberg's Arch. Pharmacol. 351, S. 305-308. Volltext nicht vorhanden.

1994

Klinker, J. F., Schwaner, I., Offermanns, S., Hagelüken, A. und Seifert, Roland (1994) Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants. Biochemical pharmacology 48 (10), S. 1857-1864.

Wenzel-Seifert, K., Schächtele, C., Hummel, R., Grünbaum, L. und Seifert, Roland (1994) Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C. Biochemical pharmacology 48 (5), S. 859-864.

Seifert, Roland, Grünbaum, L. und Schultz, Günter (1994) Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores. Naunyn-Schmiedeberg's archives of pharmacology 349 (4), S. 355-361.

Musgrave, I. F. und Seifert, Roland (1994) Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors. Biochemical pharmacology 47 (2), S. 233-239.

Hagelüken, A., Grünbaum, L., Nürnberg, B., Harhammer, R., Schunack, W. und Seifert, Roland (1994) Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins. Biochemical pharmacology 47 (10), S. 1789-1795.

Musgrave, I. F., Seifert, Roland und Schultz, Günter (1994) Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells. The Biochemical journal 301 ( Pt 2, S. 437-441.

Klinker, J. F., Hagelüken, A., Grünbaum, L., Heilmann, I., Nürnberg, B., Harhammer, R., Offermanns, S., Schwaner, I., Ervens, J, Wenzel-Seifert, K, Müller, T. und Seifert, Roland (1994) Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase. The Biochemical journal 304 ( Pt 2, S. 377-383.

Wenzel-Seifert, K., Schächtele, C. und Seifert, Roland (1994) N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions. Biochemical and biophysical research communications 200 (3), S. 1536-1543.

Naim, M., Seifert, Roland, Nürnberg, B., Grünbaum, L. und Schultz, Günter (1994) Some taste substances are direct activators of G-proteins. The Biochemical journal 297 ( Pt 3, S. 451-454.

Schlossmann, Jens, Dietmeier, K., Pfanner, N. und Neupert, W. (1994) Specific recognition of mitochondrial preproteins by the cytosolic domain of the import receptor MOM72. The journal of biological chemistry : J. Biol.Chem. 269, S. 11893-11901. Volltext nicht vorhanden.

Berger, M., Offermanns, S., Seifert, Roland und Schultz, Günter (1994) Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets. The American journal of physiology 266 (6 Pt 1), C1684-C1691.

Seifert, Roland, Hagelüken, A., Höer, A., Höer, D., Grünbaum, L., Offermanns, S., Schwaner, I., Zingel, V., Schunack, W. und Schultz, Günter (1994) The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes. Molecular Pharmacology 45 (4), S. 578-586.

Tsang, K. W., Roberts, P., Read, R. C., Kees, Frieder, Wilson, R. und Cole, P. J. (1994) The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration. The Journal of antimicrobial chemotherapy 33 (2), S. 289-297.

Honeybourne, D., Kees, Frieder K., Andrews, J. M., Baldwin, D. und Wise, R. (1994) The levels of clarithromycin and its 14-hydroxy metabolite in the lung. The European respiratory journal 7 (7), S. 1275-1280.

1993

Sedlmayr, T., Petersen, F., Raasch, W. und Kees, Frieder K. (1993) Clarithromycin, ein neues Makrolid-Antibiotikum. Wirksamkeit bei puerperalen Infektionen und Übertritt in die Muttermilch [Clarithromycin, a new macrolide antibiotic. Effectiveness in puerperal infections and pharmacokinetics in breast milk]. Geburtshilfe und Frauenheilkunde 53 (7), S. 488-491.

Wenzel-Seifert, Katharina und Seifert, Roland (1993) Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. The Journal of Immunology 150 (10), S. 4591-4599.

Klinker, J. F., Höer, A., Schwaner, I., Offermanns, S., Wenzel-Seifert, Katharina und Seifert, Roland (1993) Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. The Biochemical journaL 296 ( Pt 1, S. 245-251.

Wenzel-Seifert, Katharina und Seifert, Roland (1993) Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations. Naunyn-Schmiedeberg's archives of pharmacology 348 (1), S. 7-13.

Grobecker, H. F. und Kees, Frieder K. (1993) Pharmacokinetic parameters and haemodynamic actions of midodrine in young volunteers. International angiology : a journal of the International Union of Angiology 12 (2), S. 119-124.

Musgrave, I. F., Genieser, H. G., Maronde, E. und Seifert, Roland (1993) Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine. FEBS letters 318 (3), S. 227-230.

Dietmeier, K., Zara, V., Voos, W., Schlossmann, Jens, Moczko, M. und Pfanner, N. (1993) Targeting and translocation of the phosphate carrier/p32 to the inner membrane of yeast mitochondria. The journal of biological chemistry : J. Biol. Chem. 268, S. 25958-25964. Volltext nicht vorhanden.

1992

Dominiak, P., Kees, Frieder K., Welzel, D. und Grobecker, H. (1992) Cardiovascular parameters and catecholamines in volunteers during passive orthostasis. Influence of antihypotensive drugs. Arzneimittel-Forschung 42 (5), S. 637-642.

Krautwurst, D., Seifert, Roland, Hescheler, J. und Schultz, Günter (1992) Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production. The Biochemical journal 288 ( Pt 3, S. 1025-1035.

Klinz, F. J., Seifert, Roland, Schwaner, I., Gausepohl, H., Frank, R. und Schultz, Günter (1992) Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells. European journal of biochemistry 207 (1), S. 207-213.

Seifert, Roland, Höer, Ariane, Offermann, Stefan, Buschauer, Armin und Schunack, Walter (1992) Histamine increases Ca^2+ in dibutyryl cyclic AMP-differentiated HL-60 cells via H_1-receptors and is an incomplete secretagogue. Mol. Pharmacol. 42, S. 227-234.

Seifert, Roland, Höer, Ariane, Schwaner, Ingo und Buschauer, Armin (1992) Histamine increases cytosolic Ca^2+ in HL-60 promyelocytes predominantly via H_2-receptors with an unique agonist/antagonist profile and induces functional differentiation. Molecular Pharmacology 42, S. 235-241.

Seifert, Roland, Serke, S., Huhn, D., Bessler, W. G., Hauschildt, S., Metzger, J., Wismüller, K. H. und Jung, G. (1992) Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation. European journal of biochemistry / FEBS 203 (1-2), S. 143-151.

Offermanns, S., Seifert, Roland, Metzger, J. W., Jung, G., Lieberknecht, A., Schmidt, U. und Schultz, Günter (1992) Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochemical Journal 282 ( Pt 2, S. 551-7.

Söllner, T., Rassow, J., Wiedmann, T., Schlossmann, Jens, Neupert, W. und Pfanner, N. (1992) Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates. Nature 355, S. 84-87. Volltext nicht vorhanden.

Ervens, J. und Seifert, Roland (1992) Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism. Biochemical pharmacology 44 (4), S. 637-644.

Kees, Frieder K. (1992) Orale Cephalosporine [Oral cephalosporins]. Medizinische Monatsschrift für Pharmazeuten 15 (1), S. 2-10.

Schwaner, I., Seifert, Roland und Schultz, Günter (1992) Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways. The Biochemical journal 281 ( Pt 2, S. 301-307.

Kees, Frieder K., Raasch, W. und Grobecker, H.F. (1992) Strukturelle Charakterisierung eines unbekannten Metaboliten von Ciprofloxacin [Structural characterization of an unknown metabolite of ciprofloxacin]. Arzneimittel-Forschung 42 (4), S. 570-575.

Keil, P., Schlossmann, Jens und Pfanner, N. (1992) Targeting und translocation of mitochondrial precursor proteins. Antonie van Leeuwenhoek J. Microbiol. Serol. 61, S. 135-142. Volltext nicht vorhanden.

Schwaner, I., Seifert, Roland und Schultz, Günter (1992) The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins. Eicosanoids 5 Suppl, S10-512. Volltext nicht vorhanden.

1991

Kees, Frieder K., Lukassek, U., Naber, K. G. und Grobecker, H. (1991) Comparative investigations on the bioavailability of cefuroxime axetil. Arzneimittel-Forschung 41 (8), S. 843-846.

Seifert, Roland und Schultz, Günter (1991) The superoxide- forming NADPH oxidase of phagocytes: an enzyme system regulated by multiple mechanisms. Reviews of physiology, biochemistry, and pharmacology, 117. Springer, Berlin. ISBN 3-540-53663-9, 0-387-53663-9.

1990

Kees, Frieder K., Dehner, R., Dittrich, W., Raasch, W. und Grobecker, H. J. (1990) Untersuchungen zur Bioverfügbarkeit von Doxycy [The bioavailability of doxycycline]. Arzneimittel-Forschung 40 (9), S. 1039-1043.

Seifert, Roland, Schultz, Günter, Richter-Freund, M., Metzger, J., Wiesmüller, K. H., Jung, G., Bessler, W. G. und Hauschildt, S. (1990) Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides. The Biochemical journal 267 (3), S. 795-802.

Jungblut, P. R. und Seifert, Roland (1990) Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells. Journal of biochemical and biophysical methods 21 (1), S. 47-58.

Burde, Rahel, Buschauer, Armin und Seifert, Roland (1990) Characterization of histamine H_2-receptors in human neutrophils with a series of guanidine analogues of impromidine: Are cell type-specific H_2-receptors involved in the regulation of NADPH oxidase? Naunyn-Schmiedeberg's Archives of Pharmacology 341, S. 455-461.

Kees, Frieder K., Raasch, W., Steger, M. und Grobecker, H. (1990) High-performance liquid chromatographic assay for cefotiam and d3-cefotiam in human serum. Journal of Chromatography B 525 (2), S. 484-489.

Wenzel-Seifert, Katharina und Seifert, Roland (1990) Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells. Immunobiology 181 (4-5), S. 298-316.

Kees, Frieder K. und Naber, K. G. (1990) Pharmakokinetik von Cefixim bei Probanden und ein Literaturvergleich mit neuen Ester Prodrug Cephalosporinen [Pharmacokinetics of cefixime in volunteers and a literature comparison with the new ester prodrug cephalosporins]. Infection 18 Suppl 3, S150-S154.

Kees, Frieder K., Naber, K. G., Sigl, G., Ungethüm, W. und Grobecker, H. J. (1990) Relative bioavailability of three cefixime formulations. Arzneimittel-Forschung 40 (3), S. 293-297.

Korting, H. C., Schäfer-Korting, M., Kees, Frieder K., Lukacs, A. und Grobecker, H. (1990) Skin tissue fluid levels of cefotiam in healthy man following oral cefotiam hexetil. European journal of clinical pharmacology 39 (1), S. 33-36.

1989

Seifert, Roland, Burde, R. und Schultz, Günter (1989) Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides. The Biochemical journal 259 (3), S. 813-819.

Engel, K. J., Schmidt, W., Sonntag, H. G. und Kees, Frieder K. (1989) Comparative clinical and pharmacokinetic aspects of cefotetan versus cefoxitin plus metronidazole in vaginal hysterectomy. Journal of chemotherapy 1 (4 Supl), S. 1053-1056. Volltext nicht vorhanden.

Seifert, Roland, Jungblut, P. und Schultz, Günter (1989) Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells. Biochemical and biophysical research communications 161 (3), S. 1109-1117.

Naber, K. G., Sörgel, F., Kees, Frieder K., Schumacher, H., Sigl, G., Zürcher, J. und Berger, S. (1989) Enoxacin-Konzentrationen in der Samenflüssigkeit, im Prostatasekret und im Prostataadenomgewebe nach oraler Gabe oder intravenöser Infusion [Enoxacin concentration in seminal fluid, in prostate secretions and in prostatic adenoma tissue following oral administration or intravenous infusion]. Infection 17 Suppl 1, S30-S66.

Schmidt, H. H., Seifert, Roland und Böhme, E. (1989) Formation and release of nitric oxide from human neutrophils and HL-60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4. FEBS letters 244 (2), S. 357-360.

Rudolph, U., Koesling, D., Hinsch, K. D., Seifert, Roland, Bigalke, M., Schultz, Günter und Rosenthal, W. (1989) G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils. Molecular and cellular endocrinology 63 (1-2), S. 143-153.

Burde, Rahel, Seifert, Roland, Buschauer, Armin und Schultz, Günther (1989) Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H_2-receptors. Naunyn-Schmiedeberg's archives of pharmacology 340, S. 671-678.

Seifert, Roland und Schultz, Günter (1989) Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides. Trends in pharmacological sciences 10 (9), S. 365-369.

Seifert, Roland, Burde, R. und Schultz, Günter (1989) Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells. Naunyn-Schmiedeberg's archives of pharmacology 340 (1), S. 101-106.

Kees, Frieder K., Naber, K. G., Meyer, G. P. und Grobecker, H. (1989) Pharmacokinetics of ciprofloxacin in elderly patients. Arzneimittel-Forschung 39 (4), S. 523-527.

Naber, K. G., Sörgel, F., Kees, Frieder K., Jaehde, U. und Schumacher, H. (1989) Pharmacokinetics of ciprofloxacin in young (healthy volunteers) and elderly patients, and concentrations in prostatic fluid, seminal fluid, and prostatic adenoma tissue following intravenous administration. The American journal of medicine 87 (5supl1), S57-S59.

Seifert, Roland, Wenzel, Katharina, Eckstein, F. und Schultz, Günter (1989) Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins. European journal of biochemistry / FEBS 181 (1), S. 277-285.

Kujath, P., Düsel, W., Bruch, H. P. und Kees, Frieder K. (1989) The pharmacokinetic properties of cefotetan and its relevance for prophylaxis in elective colorectal surgery. Journal of chemotherapy 1 (4 Supl), S. 1002-1004. Volltext nicht vorhanden.

1988

Seifert, Roland, Schächtele, C., Rosenthal, W. und Schultz, Günter (1988) Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol. Biochemical and biophysical research communications 154 (1), S. 20-26.

Engel, K. J., Schmidt, W., Sonntag, H. G. und Kees, Frieder K. (1988) Comparative clinical and pharmacokinetic aspects of cefotetan versus cefoxitin plus metronidazole in vaginal hysterectomy. Chemioterapia 7 (4), S. 256-260. Volltext nicht vorhanden.

Naber, K. G., Sörgel, F., Kees, Frieder K., Schumacher, H., Metz, R. und Grobecker, H. (1988) In-vitro activity of fleroxacin against isolates causing complicated urinary tract infections and concentrations in seminal and prostatic fluid and in prostatic adenoma tissue. The Journal of antimicrobial chemotherapy 22 Suppl D, S. 199-207.

Kees, Frieder K., Naber, K. G., Schumacher, H. und Grobecker, H. (1988) Penetration of fleroxacin into prostatic secretion and prostatic adenoma tissue. Chemotherapy 34 (6), S. 437-443. Volltext nicht vorhanden.

Schächtele, C., Seifert, Roland und Osswald, H. (1988) Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. Biochemical and biophysical research communications 151 (1), S. 542-547.

Seifert, Roland und Schächtele, C. (1988) Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase. Biochemical and biophysical research communications 152 (2), S. 585-592.

Kujath, P., Düsel, W., Bruch, H. P. und Kees, Frieder K. (1988) The pharmacokinetic properties of cefotetan and its relevance for prophylaxis in elective colorectal surgery. Chemioterapia 7 (4), S. 229-232. Volltext nicht vorhanden.

Seifert, Roland, Rosenthal, W., Schultz, Günter, Wieland, T., Gierschick, P. und Jakobs, K. H. (1988) The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides. European journal of biochemistry / FEBS 175 (1), S. 51-55.

1987

Seifert, Roland, Schächtele, C. und Schultz, Günter (1987) Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol. Biochemical and biophysical research communications 149 (2), S. 762-768.

Naber, K., Kees, Frieder K., Denk, K., Bauernfeind, A. und Grobecker, H. (1987) Carumonam versus ceftazidime: in vitro activity, pharmacokinetics in elderly patients, safety and therapeutic efficacy in the treatment of complicated urinary tract infections. Chemioterapia 6 (2 Supl), S. 517-518. Volltext nicht vorhanden.

Seifert, Roland und Schultz, Günter (1987) Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is potentiated by stable guanine nucleotides. European journal of biochemistry / FEBS 162 (3), S. 563-569.

Naber, K. G., Adam, D. und Kees, Frieder K. (1987) In vitro activity and concentrations in serum, urine, prostatic secretion and adenoma tissue of ofloxacin in urological patients. Drugs 34 Suppl 1, S44-S50. Volltext nicht vorhanden.

Seifert, Roland und Schultz, Günter (1987) Reversible activation of NADPH oxidase in membranes of HL-60 human leukemic cells. Biochemical and biophysical research communications 146 (3), S. 1296-1302.

Kees, Frieder K., Dominiak, P. und Grobecker, H. (1987) Untersuchungen zur Bioverfügbarkeit von Heptaminol bei Probanden [Bioavailability of heptaminol in healthy subjects]. Arzneimittel-Forschung 37 (10), S. 1182-1185.

Grobecker, H., Kees, Frieder K., Linden, M., Schrader, E. und Welte, S. (1987) Untersuchungen zur Bioverfügbarkeit von Midodrin und 2,5- Dimethoxyphenyl-ß-aminoethanol-hydrochlorid [The bioavailability of midodrin and alpha-2,5-dimethoxyphenyl-beta-aminoethanol hydrochloride]. Arzneimittel-Forschung 37 (4), S. 447-450.

1986

Dominiak, P., Kees, Frieder K. und Grobecker, H. (1986) Circulating and tissue catecholamines in rats with chronic neurogenic hypertension. Basic research in cardiology 81 (1), S. 20-28.

Seifert, Roland, Rosenthal, W. und Schultz, Günter (1986) Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils. FEBS letters 205 (1), S. 161-165.

Martinez, C., Dominiak, P., Kees, Frieder K. und Grobecker, H. (1986) Inhibition of monoamine oxidase by viloxazine in rats. Arzneimittel-Forschung 36 (5), S. 800-803.

Seifert, Roland (1986) Nikotinamidmethylierung in normalen Geweben und Tumorzellen von Ratte und Maus. Dissertation, Berlin, Freie Universität.

Naber, K. G., Dette, G. A., Kees, Frieder K., Knothe, H. und Grobecker, H. (1986) Pharmacokinetics, in-vitro activity, therapeutic efficacy and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections. The Journal of antimicrobial chemotherapy 17 (4), S. 517-527.

1985

Grobecker, H., Gessler, I., Delius, W., Dominiak, P. und Kees, Frieder K. (1985) Effect of ketanserin on hemodynamics, plasma-catecholamine concentrations, and serotonin uptake by platelets in volunteers and patients with congestive heart failure. Journal of cardiovascular pharmacology 7, Suppl 7, S102-S104.

Kees, Frieder K., Naber, K. G., Bartoschik-Wich, B., Stockmann, P., Meyer, G. P. und Grobecker, H. (1985) High-performance liquid chromatography analysis of mezlocillin, piperacillin, their degradation products, and of ioxitalamic acid in plasma and urine of healthy volunteers. Arzneimittel-Forschung 35 (7), S. 1099-1104.

Dominiak, P., Kees, Frieder K. und Grobecker, H. (1985) Sympathoadrenal dysfunction in rats with chronic neurogenic hypertension. European journal of pharmacology 107 (2), S. 263-266.

1984

Dominiak, P., Kees, Frieder K. und Grobecker, H. (1984) Changes in peripheral and central catecholaminergic and serotoninergic neurons of rats after acute and subacute administration of nicotine. Klinische Wochenschrift. Supplementum 62 Suppl 2, S. 76-80. Volltext nicht vorhanden.

Kees, Frieder K., Grobecker, H. und Naber, K. G. (1984) High-performance liquid chromatographic analysis of cefotetan epimers in human plasma and urine. Journal of Chromatography B 305 (2), S. 363-371.

1983

Schleicher, E. D., Kees, Frieder K. und Wieland, O. H. (1983) Analysis of total urinary catecholamines by liquid chromatography: methodology, routine experience and clinical interpretations of results. Clinica chimica acta 129 (3), S. 295-302.

Kees, Frieder K., Strehl, E., Dominiak, P., Grobecker, H., Seeger, K., Seidel, G., Neuhaus, B. und Safrany, L. (1983) Cefotaxime and desacetyl cefotaxime in human bile. Infection 11 (2), S. 118-120.

Naber, K. G., Kees, Frieder K. und Grobecker, H. (1983) Ceftazidime: pharmacokinetics in young volunteers versus elderly patients and therapeutic efficacy with complicated urinary tract infections. The Journal of antimicrobial chemotherapy 12 Suppl A, S. 41-45.

1981

Kees, Frieder K., Strehl, E., Seeger, K., Seidel, G., Dominiak, P. und Grobecker, H. (1981) Comparative determination of cefotaxime and desacetyl cefotaxime in serum and bile by bioassay and high-performance liquid chromatography. Arzneimittel-Forschung 31 (2), S. 362-365.

1976

Kees, Frieder K. (1976) Thiaziridindioxide, Thiadiaziridindioxide und ein Beitrag zur Staudinger-Pfenninger-Reaktion. Dissertation, Univ. Würzburg. Volltext nicht vorhanden.

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