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Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis

Seifert, Roland and Dove, Stefan (2012) Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis. Trends in microbiology 20 (7), pp. 343-351.

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Abstract

Whooping cough is a very important medical problem that requires novel approaches for treatment. The disease is caused by Bordetella pertussis, with the calmodulin (CaM)-activated adenylyl cyclase (AC) toxin (also known as CyaA) being a major virulence factor. Hence, CyaA inhibitors could constitute novel therapeutics, but it has been difficult to develop potent drugs with high selectivity over ...

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Item Type:Article
Date:2012
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
22578665PubMed ID
10.1016/j.tim.2012.04.002DOI
Classification:
NotationType
Adenylate Cyclase Toxin/chemistryMESH
Anti-Bacterial Agents/pharmacologyMESH
Bordetella pertussis/enzymologyMESH
Enzyme Inhibitors/pharmacologyMESH
HumansMESH
Models, MolecularMESH
Protein ConformationMESH
Ribonucleotides/pharmacologyMESH
Subjects:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Prof. Dr. Stefan Dove
Deposited On:15 Nov 2012 09:33
Last Modified:15 Nov 2012 14:43
Item ID:26717
Owner Only: item control page
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