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In-vitro activity of fleroxacin against isolates causing complicated urinary tract infections and concentrations in seminal and prostatic fluid and in prostatic adenoma tissue

Naber, K. G. and Sörgel, F. and Kees, Frieder K. and Schumacher, H. and Metz, R. and Grobecker, H. (1988) In-vitro activity of fleroxacin against isolates causing complicated urinary tract infections and concentrations in seminal and prostatic fluid and in prostatic adenoma tissue. The Journal of antimicrobial chemotherapy 22 Suppl D, pp. 199-207.

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Abstract

Fleroxacin is a new fluoroquinolone with a broad antibacterial spectrum and a serum half-life of about 8-12 h. Eighty percent of 400 isolates from complicated or hospital-acquired urinary tract infections were inhibited by a concentration of 1 mg/l and 95% by 4 mg/l. As with other quinolones, fleroxacin is less active in acid urine (pH 5.4) than in Mueller-Hinton broth (pH 7.4). In 12 healthy ...

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Item Type:Article
Date:1988
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
2462556PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
Aged, 80 and overMESH
Anti-Infective Agents/therapeutic useMESH
Body Fluids/metabolismMESH
Ciprofloxacin/therapeutic useMESH
FleroxacinMESH
Gram-Negative Bacteria/drug effectsMESH
Gram-Positive Bacteria/drug effectsMESH
HumansMESH
MaleMESH
Microbial Sensitivity TestsMESH
Middle AgedMESH
Prostatic Hyperplasia/metabolismMESH
Seminal Vesicles/metabolismMESH
Urinary Tract Infections/microbiologyMESH
Subjects:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:30 Nov 2012 10:30
Last Modified:13 Mar 2014 19:29
Item ID:26841
Owner Only: item control page
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