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Distinct interaction of human and guinea pig histamine H_2-Receptor with guanidine-type agonists,

Kelley, Melissa T. and Bürckstümmer, Tilmann and Wenzel-Seifert, Katharina and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2001) Distinct interaction of human and guinea pig histamine H_2-Receptor with guanidine-type agonists,. Molecular Pharmacology 60 (6), pp. 1210-1225.

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Other URL: http://molpharm.aspetjournals.org/cgi/content/full/60/6/1210


Abstract

It is unknown why the potencies and efficacies of long-chained guanidine-type histamine H2-receptor (H2R) agonists are lower at the H2R of human neutrophils than at the H2R of the guinea pig atrium. To elucidate these differences, we analyzed fusion proteins of the human H2R (hH2R) and guinea pig H2R (gpH2R), respectively, and the short splice variant of Gsalpha (Gsalpha S) expressed in Sf9 ...

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Item Type:Article
Date:2001
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
UNSPECIFIEDDOI
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Prof. Armin Buschauer
Deposited On:22 Feb 2008 07:34
Last Modified:05 Aug 2009 13:42
Item ID:3403
Owner Only: item control page
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