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Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part II. Studies on the influence of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] dichloroplatinum(II) on the specific immune defense in MXT-M-3,2 breast cancer bearing mice

Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Schönenberger, Helmut (2000) Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part II. Studies on the influence of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] dichloroplatinum(II) on the specific immune defense in MXT-M-3,2 breast cancer bearing mice. Archiv der Pharmazie 333 (12), pp. 397-403.

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Abstract

The anti-tumor activity of [meso-1,2-bis(2,6-dichloro-4- hydroxyphenyl)ethylenediamine]dichloroplatinum(II) on the MXT-M-3,2 breast cancer implanted into B6D2F1 mice was not significantly reduced by splenectomy or co-administration of cyclosporine A. Neither did the use of T-lymphocyte-deficient NMRI (nu/nu) mice as hosts substantially influence its anti-tumor effect. Obviously, [meso-1,2-bis(2,6-dichloro-4- hydroxyphenyl)ethylenediamine]dichloroplatinum(II) does not act by an enhancement of the specific immune defense.

Item Type:

Article

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)

Projects:

SFB 234

Identification Number:

Value	Type
11199469	PubMed ID
10.1002/1521-4184(200012)333:12<397::AID-ARDP397>3.0.CO;2-F	DOI

Classification:

Notation	Type
Animals	MESH
Antineoplastic Agents/pharmacology	MESH
Breast Neoplasms/drug therapy	MESH
Cyclosporine/pharmacology	MESH
Female	MESH
Humans	MESH
Immunity/drug effects	MESH
Immunologic Factors/pharmacology	MESH
Immunosuppressive Agents/pharmacology	MESH
Mice	MESH
Mice, Inbred Strains	MESH
Organoplatinum Compounds/pharmacology	MESH
T-Lymphocytes/drug effects	MESH
Transplantation, Heterologous	MESH
Tumor Cells, Cultured	MESH