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Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part II. Studies on the influence of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] dichloroplatinum(II) on the specific immune defense in MXT-M-3,2 breast cancer bearing mice

Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Schönenberger, Helmut (2000) Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part II. Studies on the influence of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] dichloroplatinum(II) on the specific immune defense in MXT-M-3,2 breast cancer bearing mice. Archiv der Pharmazie 333 (12), pp. 397-403.

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Abstract

The anti-tumor activity of [meso-1,2-bis(2,6-dichloro-4- hydroxyphenyl)ethylenediamine]dichloroplatinum(II) on the MXT-M-3,2 breast cancer implanted into B6D2F1 mice was not significantly reduced by splenectomy or co-administration of cyclosporine A. Neither did the use of T-lymphocyte-deficient NMRI (nu/nu) mice as hosts substantially influence its anti-tumor effect. Obviously, ...

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Item Type:Article
Date:2000
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
11199469PubMed ID
10.1002/1521-4184(200012)333:12<397::AID-ARDP397>3.0.CO;2-FDOI
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/pharmacologyMESH
Breast Neoplasms/drug therapyMESH
Cyclosporine/pharmacologyMESH
FemaleMESH
HumansMESH
Immunity/drug effectsMESH
Immunologic Factors/pharmacologyMESH
Immunosuppressive Agents/pharmacologyMESH
MiceMESH
Mice, Inbred StrainsMESH
Organoplatinum Compounds/pharmacologyMESH
T-Lymphocytes/drug effectsMESH
Transplantation, HeterologousMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:14 Jan 2009 14:09
Last Modified:19 Aug 2010 11:27
Item ID:4840
Owner Only: item control page
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