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Functional Selectivity of GPCR Ligand Stereoisomers: New Pharmacological Opportunities

Seifert, Roland and Dove, Stefan (2009) Functional Selectivity of GPCR Ligand Stereoisomers: New Pharmacological Opportunities. Mol. Pharmacol. 75 (1), pp. 13-18.

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Abstract

It is now well established that any given ligand for a G-protein coupled receptor (GPCR) does not simply possess a single defined efficacy. Rather, a ligand possesses multiple efficacies, depending on the specific down-stream signal transduction pathway analyzed. This diversity may be based on ligand-specific GPCR conformations and is often referred to as “Functional Selectivity”. It has been ...

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Item Type:Article
Date:2009
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
mol.108052944v1Other
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Stefan Dove
Deposited On:20 Jan 2009 14:04
Last Modified:05 Aug 2009 13:50
Item ID:5464
Owner Only: item control page
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