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Molecular analysis of the histamine H3-receptor

URN to cite this document:
urn:nbn:de:bvb:355-epub-125520
Schnell, David
Date of publication of this fulltext: 18 Feb 2010 13:12


Abstract (English)

The histamine H3 receptor (H3R) is a biogenic amine receptor that belongs to family I of G protein-coupled receptors (GPCRs). During the past two decades, the H3R has gained much interest in academia and industry. The H3Rs is predominantly localized in the brain and regulates the release of histamine as well as other neurotransmitters into the synaptic cleft via negative feedback mechanisms. ...

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Translation of the abstract (German)

Der Histamin H3-Rezeptor (H3R) gehört zur Superfamilie der G-Protein-gekoppelten Rezeptoren (GPCRs). Die Klonierung des H3R hat bei Wissenschaftlern im akademischen Bereich und in der Industrie großes Interesse geweckt. Der H3Rs wird hauptsächlich im Gehirn exprimiert und reguliert die Ausschüttung von Histamin und anderen Neurotransmittern in den synaptischen Spalt über negative ...

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