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Molecular analysis of the histamine H3-receptor

Schnell, David (2010) Molecular analysis of the histamine H3-receptor. PhD, Universität Regensburg.

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Date of publication of this fulltext: 18 Feb 2010 13:12

Abstract (English)

The histamine H3 receptor (H3R) is a biogenic amine receptor that belongs to family I of G protein-coupled receptors (GPCRs). During the past two decades, the H3R has gained much interest in academia and industry. The H3Rs is predominantly localized in the brain and regulates the release of histamine as well as other neurotransmitters into the synaptic cleft via negative feedback mechanisms. ...


Translation of the abstract (German)

Der Histamin H3-Rezeptor (H3R) gehört zur Superfamilie der G-Protein-gekoppelten Rezeptoren (GPCRs). Die Klonierung des H3R hat bei Wissenschaftlern im akademischen Bereich und in der Industrie großes Interesse geweckt. Der H3Rs wird hauptsächlich im Gehirn exprimiert und reguliert die Ausschüttung von Histamin und anderen Neurotransmittern in den synaptischen Spalt über negative ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:18 February 2010
Referee:Prof. Dr. Roland Seifert
Date of exam:22 January 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Keywords:Histamin, G-Protein gekoppelter Rezeptor, Radioaktivität, Molekulare Pharmakologie, Funktionelle Selektivität, Proxyfan, Konstitutive Aktivität, Signaltransduktion, Ligand-Rezeptor-Wechselwirkungen, Medizinische Chemie, Zielgerichtete Mutagenese; histamine, G protein-coupled receptor, radioactivity, signal transduction, constitutive activity, medicinal chemistry, functional selectivity, proxyfan, protean agonism, molecular pharmacology, site-directed mutagenesis, ligand-receptor interactions
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:12552
Owner only: item control page


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