Ghorai, Prasanta, Kraus, Anja, Birnkammer, Tobias, Geyer, Roland, Bernhardt, Günther, Dove, Stefan, Seifert, Roland, Elz, Sigurd and Buschauer, Armin (2010) Chiral N(G)-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. Bioorganic & Medicinal Chemistry Letters 20 (10), pp. 3173-3176.
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Abstract
A set of chiral imidazolylpropylguanidines and 2-aminothiazolylpropylguanidines bearing N(G)-3-phenyl- or N(G)-3-cyclohexylbutanoyl residues was synthesized and investigated for histamine H2 receptor (H2R) agonism (guinea pig (gp) right atrium, GTPase assay on recombinant gp and human (h) H2R) and for hH2R selectivity compared to hH1R, hH3R and hH4R. In contrast to previous studies on arpromidine ...
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| Item type: | Article | ||||||
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| Date: | 27 March 2010 | ||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) | ||||||
| Projects: | GRK 760, Graduiertenkolleg Medizinische Chemie | ||||||
| Identification Number: |
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| Keywords: | histamine; H2 receptor agonist; chiral; enantiomers; acylguanidine; Sf9 cells | ||||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Item ID: | 13775 |
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