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Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells

Schnell, David ; Brunskole, Irena ; Ladova, Katerina ; Schneider, Erich H. ; Igel, Patrick ; Dove, Stefan ; Buschauer, Armin ; Seifert, Roland



Abstract

The histamine H4-receptor (H4R) is expressed on cells of the immune system including eosinophils, dendritic cells and T cells and plays an important role in the pathogenesis of bronchial asthma, atopic dermatitis and pruritus. Analysis of the H4R in these diseases depends on the use of animal models. However, there are substantial pharmacological differences between various H4R species orthologs. ...

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