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Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells

Schnell, David, Brunskole, Irena, Ladova, Katerina, Schneider, Erich H., Igel, Patrick, Dove, Stefan, Buschauer, Armin and Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), pp. 457-470.

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Other URL: http://www.springerlink.com/content/p3u17q42n1802256/, http://www.springerlink.com/content/p3u17q42n1802256/fulltext.pdf


The histamine H4-receptor (H4R) is expressed on cells of the immune system including eosinophils, dendritic cells and T cells and plays an important role in the pathogenesis of bronchial asthma, atopic dermatitis and pruritus. Analysis of the H4R in these diseases depends on the use of animal models. However, there are substantial pharmacological differences between various H4R species orthologs. ...


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Item type:Article
Date:26 February 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
21359967PubMed ID
Keywords:histamine H4-receptor, histamine, receptor species orthologs, JNJ7777120, GTPase, Sf9 insect cells
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:18359
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