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Ambivalence of drug metabolism: Exploration of cilazapril and candesartan prodrugs for transdermal delivery and search for toxic reactive intermediates of N(G)-acylated hetarylpropylguanidines

URN to cite this document:
urn:nbn:de:bvb:355-epub-215664
Ertel, Miriam
Date of publication of this fulltext: 19 Jul 2012 09:00


Abstract (English)

Figuratively, drug metabolism can be considered as two sides of the same coin; one leading to desired, beneficial effects, e.g. by activation of prodrugs, whereas the other one results in adverse side effects due to toxic metabolites. In this work both aspects were explored. Transdermal therapeutic systems (TTS) are known as drug formulations providing constant and sustained drug plasma levels ...

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Translation of the abstract (German)

Der Wirkstoffmetabolismus gleicht zwei Seiten einer Medaille. Während die eine zu erwünschten Effekten führt, wie z.B. zur Aktivierung von Prodrugs, resultiert die andere in unerwünschten Nebenwirkungen aufgrund von toxischen Metaboliten. Beide Aspekte werden in dieser Arbeit betrachtet. Transdermale therapeutische Systeme (TTS) bewirken konstante, langanhaltende Blutspiegel bei geringer ...

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