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Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods

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Lopuch, Miroslaw
Date of publication of this fulltext: 17 Oct 2011 09:39

Abstract (English)

In the last three decades, a large amount of experimental data (for example Förster resonance energy transfer (FRET) at fluorescently labelled receptors) supported the hypothesis of the dimerization of G-protein-coupled receptors (GPCR), including neuropeptide Y (NPY YxR) and histamine (HxR) receptors. Targeting GPCR dimers could be helpful to understand (patho)physiological processes and may be ...


Translation of the abstract (German)

Die Hypothese der Dimerisierung G-Protein-gekoppelter Rezeptoren (GPCR), einschließlich Neuropeptid Y (NPY, YxR) und Histamin-Rezeptoren (HxR), wird durch experimentelle Befunde (z. B. mittels Förster-Resonanzenergietransfer (FRET) gestützt. Ein Targeting solcher GPCR-Dimere könnte dazu beitragen, (patho)physiologische Prozesse besser zu verstehen und lässt sich möglicherweise therapeutisch ...


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