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Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships

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Geyer, Roland
Date of publication of this fulltext: 14 Dec 2011 09:47

Abstract (English)

The recently discovered histamine H4 receptor (H4R) is reported to be involved in immunological processes and inflammatory diseases. However, the (patho)physiological role of the H4R is far from being fully understood. Controversial data on H4R agonists as well as reports on β-arrestin-mediated signaling and partial agonistic effects of the standard H4R antagonist JNJ-7777120 at certain H4R ...


Translation of the abstract (German)

Der kürzlich entdeckte Histamin H4-Rezeptor (H4R) scheint eine entscheidende Rolle in immunologischen und entzündungsrelevanten Prozessen zu spielen. Allerdings ist die (patho)physiologische Rolle des H4R bei weitem nicht vollständig verstanden. Widersprüchliche Daten über H4R Agonisten sowie Berichte über β-Arrestin-vermittelte Signalwege und partialagonistische Wirkung des H4R Antagonisten ...


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