Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-232576
DOI to cite this document:: 10.5283/epub.23257

Seifert, Roland ; Jungblut, P. ; Schultz, Günter

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Date of publication of this fulltext: 24 Jan 2012 13:31

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Abstract

Activation of NADPH oxidase in undifferentiated HL-60 leukemic cells and in HL-60 cells differentiated along the myeloid pathway with dibutyryl cyclic AMP (dbcAMP) or dimethyl sulfoxide (Me2SO) was studied. Upon stimulation with a calcium ionophore, a phorbol ester, arachidonic acid or gamma-hexachlorocyclohexane, Me2SO-differentiated HL-60 cells generated superoxide (O2-) at higher rates than ...