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Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins

URN to cite this document:
urn:nbn:de:bvb:355-epub-232581
Seifert, Roland ; Wenzel, Katharina ; Eckstein, F. ; Schultz, Günter
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Date of publication of this fulltext: 24 Jan 2012 13:30


Abstract

Whereas the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe), induced NADPH-oxidase-catalyzed superoxide (O2-) formation in human neutrophils, purine and pyrimidine nucleotides per se did not stimulate NADPH oxidase but enhanced O2- formation induced by submaximally and maximally stimulatory concentrations of fMet-Leu-Phe up to fivefold. On the other hand, ...

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