Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol

URN to cite this document:: urn:nbn:de:bvb:355-epub-232713
DOI to cite this document:: 10.5283/epub.23271

Seifert, Roland ; Schächtele, C. ; Schultz, Günter

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Date of publication of this fulltext: 26 Jan 2012 08:31

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Abstract

Octadecadienoic acids (linoleic acid and linolelaidic acid) and the diacylglycerol, 1-oleoyl-2-acetyl-rac-glycerol (OAG) concentration-dependently induced activation of gel-filtered human platelets, i.e. aggregation and phosphorylation of 20 kDa and 47 kDa peptides. In contrast, octadecenoic acids (oleic and elaidic acid) and octadecanoic (stearic) acid were inactive. Octadecadienoic acid-induced ...