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Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH1R, but low affinity to hH4R

Wagner, Eva ; Wittmann, Hans-Joachim ; Elz, Sigurd ; Strasser, Andrea



Abstract

In literature, a synergism between histamine H-1 and H-4 receptor is discussed. Furthermore, it was shown, that the combined application of mepyramine, a H-1 antagonist and JNJ7777120, a H-4 receptor ligand leads to a synergistic effect in the acute murine asthma model. Thus, the aim of this study was to develop new hybrid ligands, containing one H-1 and one H-4 pharmacophor, connected by an ...

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