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Na-methylated phenylhistamines exhibit affinity to the hH4R - a pharmacological and molecular modelling study

Wittmann, Hans-Joachim ; Elz, Sigurd ; Seifert, Roland ; Strasser, Andrea



Abstract

Histamine H-1-receptor agonists and antagonists exhibit affinity to the human histamine H-4-receptor (hH(4)R). However, the pharmacological profiles between hH(1)R and hH(4)R exhibit similarities and differences. Since suprahistaprodifen and trifluoromethylphenylhistamine show significant affinity to hH(4)R, the aim of this study was to analyse a large number of new phenylhistamines, ...

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