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In search for potent and selective NPY Y4 receptor ligands: acylguanidines, argininamides and peptide analogs

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Kaske, Melanie
Date of publication of this fulltext: 03 Jun 2013 12:39

Abstract (English)

The neuropeptide Y hormone family consists of three 36-amino acid peptides, namely neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP), involved in the regulation of numerous physiological processes such as food intake, blood pressure, stress, pain and hormone secretion. Among the four NPY receptor subtypes (Y1R, Y2R, Y4R, Y5R) activated by the NPY peptide family in humans, the ...


Translation of the abstract (German)

Neuropeptid Y (NPY), Peptid YY (PYY) und pankreatisches Polypeptid (PP) bestehen jeweils aus 36 Aminosäuren und gehören zur Neuropeptid Y Familie, welche an der Regulation verschiedener physiologischer Prozesse wie z.B. Nahrungsaufnahme, Blutdruck-Regulation, Stress, Schmerz und Hormonausschüttung beteiligt ist. Unter den vier humanen NPY-Rezeptorsubtypen (Y1, Y2, Y4, Y5) nimmt der Y4R eine ...


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