Memminger, Martin, Keller, Max, Lopuch, Miroslaw, Pop, Nathalie, Bernhardt, Günther, von Angerer, Erwin and Buschauer, Armin (2012) The Neuropeptide Y Y1 receptor: a diagnostic marker? Expression in MCF-7 breast cancer cells is down-regulated by antiestrogens in vitro and in xenografts. PLoS ONE 7 (12), e51032.
| License: Creative Commons Attribution 3.0 PDF - Published Version Memminger et al., PLoS ONE 7(12): e51032. doi:10.1371/journal.pone.0051032 Download (2MB) | |
| PDF - Supplemental Material Supporting Information Download (239kB) |
Abstract
The neuropeptide Y (NPY) Y1 receptor (Y1R) has been suggested as a tumor marker for in vivo imaging and as a therapeutic target. In view of the assumed link between estrogen receptor (ER) and Y1R in mammary carcinoma and with respect to the development of new diagnostic tools we investigated the Y1R protein expression in human MCF-7 cell variants differing in ER content and sensitivity against ...
Export bibliographical data
| Item type: | Article | ||||||
|---|---|---|---|---|---|---|---|
| Date: | 7 December 2012 | ||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||||
| Projects: | GRK 760, Graduiertenkolleg Medizinische Chemie, Open Access Publizieren (DFG) | ||||||
| Identification Number: |
| ||||||
| Keywords: | neuropeptide Y; Y1 receptor; G-protein coupled receptor; estrogen receptor; imaging; MCF-7 breast cancer; xenograft; nude mice; autoradiography; radioligand; [3H]-UR-MK114; argininamides; antiestrogen; tamoxifen; diagnostic marker | ||||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences 600 Technology > 615 Pharmacy | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Item ID: | 26578 |
Owner only: item control page
Download Statistics