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The Neuropeptide Y Y1 receptor: a diagnostic marker? Expression in MCF-7 breast cancer cells is down-regulated by antiestrogens in vitro and in xenografts

URN to cite this document:
urn:nbn:de:bvb:355-epub-265783
DOI to cite this document:
10.5283/epub.26578
Memminger, Martin ; Keller, Max ; Lopuch, Miroslaw ; Pop, Nathalie ; Bernhardt, Günther ; von Angerer, Erwin ; Buschauer, Armin
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Memminger et al., PLoS ONE 7(12): e51032. doi:10.1371/journal.pone.0051032
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Date of publication of this fulltext: 30 Oct 2012 15:02


Abstract

The neuropeptide Y (NPY) Y1 receptor (Y1R) has been suggested as a tumor marker for in vivo imaging and as a therapeutic target. In view of the assumed link between estrogen receptor (ER) and Y1R in mammary carcinoma and with respect to the development of new diagnostic tools we investigated the Y1R protein expression in human MCF-7 cell variants differing in ER content and sensitivity against ...

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