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Molecular and cellular analysis of human histamine receptor subtypes

Seifert, Roland ; Strasser, Andrea ; Schneider, Erich H. ; Neumann, Detlef ; Dove, Stefan ; Buschauer, Armin


The human histamine receptors hH1R and hH2R constitute important drug targets, and hH3R and hH4R have substantial potential in this area. Considering the species-specificity of pharmacology of HxR orthologs, it is important to analyze hHxRs. Here, we summarize current knowledge of hHxRs endogenously expressed in human cells and hHxRs recombinantly expressed in mammalian and insect cells. We ...


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