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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-26664
Alternative Links zum Volltext:DOI
Zusammenfassung
Abstract—Adenylyl cyclases (ACs) are promising pharmacological targets for treating heart failure, cancer, and psychosis. Ribosesubstituted nucleotides have been reported as a potent family of AC inhibitors. In silico analysis of the docked conformers of such nucleotides in AC permits assembly of a consistent, intuitive QSAR model with strong correlation relative to measured pKi values. Energy ...
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