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Constitutive Activity and Ligand Selectivity of Human,
Guinea Pig, Rat, and Canine Histamine H₂ Receptors

Preuss, Hendrik, Ghorai, Prasanta, Kraus, Anja, Dove, Stefan, Buschauer, Armin and Seifert, Roland (2007) Constitutive Activity and Ligand Selectivity of Human,
Guinea Pig, Rat, and Canine Histamine H₂ Receptors.
Journal of Pharmacology and Experimental Therapeutics 321 (3), pp. 983-995.

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Date of publication of this fulltext: 05 Aug 2009 13:40

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Abstract

Previous studies revealed pharmacological differences between human and guinea pig histamine H₂ receptors (H₂Rs) with respect to the interaction with guanidine-type agonists. Because H₂R species variants are structurally very similar, comparative studies are suited to relate different properties of H₂R species isoforms to few molecular determinants. Therefore, we systematically compared H₂Rs of ...

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Item type:Article
Date:1 March 2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1124/jpet.107.120014DOI
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:2670
Owner only: item control page

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