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Constitutive Activity and Ligand Selectivity of Human,
Guinea Pig, Rat, and Canine Histamine H₂ Receptors

URN to cite this document:
Preuss, Hendrik ; Ghorai, Prasanta ; Kraus, Anja ; Dove, Stefan ; Buschauer, Armin ; Seifert, Roland
Date of publication of this fulltext: 05 Aug 2009 13:40


Previous studies revealed pharmacological differences between human and guinea pig histamine H₂ receptors (H₂Rs) with respect to the interaction with guanidine-type agonists. Because H₂R species variants are structurally very similar, comparative studies are suited to relate different properties of H₂R species isoforms to few molecular determinants. Therefore, we systematically compared H₂Rs of ...


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